Drugs / CAR-T cells
last change Aug 2026 re-read 2 minutes ago

CAR-T cells

Cell therapy targets AXL, CD19, EGFR, GPC3, GPRC5D, GUCY2C, MUC1, PSCA via depletion

Developed for
plasma cell myeloma · acute lymphoblastic leukemia · B-cell non-Hodgkin lymphoma · adult acute lymphoblastic leukemia · gliosarcoma · hematopoietic and lymphoid cell neoplasm · non-Hodgkin lymphoma · acute myeloid leukemia
+17 more · autoimmune thrombocytopenia · gastric adenocarcinoma · glioblastoma · hematologic disorder · HIV infectious disease · Hodgkins lymphoma · leukemia · lung cancer · lupus nephritis · lymphoid leukemia · lymphoma · malignant pancreatic neoplasm · neuromyelitis optica · non-small cell lung carcinoma · plasmacytoma · pleural neoplasm · precursor B-cell acute lymphoblastic leukemia
Investigated by
Institute of Hematology & Blood Diseases Hospital, China · Zhejiang University · Jingzhou Central Hospital · Second Affiliated Hospital of Guangzhou Medical University · Shenzhen Geno-Immune Medical Institute · Shenzhen Second People's Hospital
+51 more · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan Sian Medical Technology Co., Ltd · Xiangyang Central Hospital · Yake Biotechnology Ltd. · 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China · AFA Insurance · Affiliated Hospital of Jiangnan University · Affiliated Hospital to Academy of Military Medical Sciences · Apollo Hospital, New Delhi, India · Baylor College of Medicine · Beijing 302 Hospital · Beijing Immunochina Medical Science & Technology Co., Ltd. · Beijing Lu Daopei Hospital · Chembrain LTD · Chongqing Precision Biotech Co., Ltd · Daniel Landi · Duke Cancer Institute · Fapon Biotherapy Inc. · First Affiliated Hospital of Zhejiang University · Gary Archer Ph.D. · Guangdong Zhaotai InVivo Biomedicine Co. Ltd. · Guangzhou 8th People's Hospital · Guangzhou Anjie Biomedical Technology Co., Ltd. · Guangzhou Women and Children's Medical Center · Hebei Senlang Biotechnology Inc., Ltd. · Hebei Yanda Ludaopei Hospital · Henan Cancer Hospital · Henan Hualong Biotechnology Company · Hunan Cancer Hospital · Hunan Zhaotai Yongren Medical Innovation Co. Ltd. · Juventas Cell Therapy Ltd. · Jyväskylä Central Hospital · National Cancer Institute (NCI) · National University of Malaysia · People Hospital Of Yichang · Plutonet Sdn Bhd · Ruijin Hospital · Sichuan University · Sun Yat-sen University · Suzhou Immunofoco Biotechnology Co., Ltd · The First Affiliated Hospital of Guangdong Pharmaceutical University · The First People's Hospital of Yuhang District · The Methodist Hospital Research Institute · Tsinghua University · University of Oulu · University of Technology, Sydney · Uppsala University · Uppsala University Hospital · West China Hospital · Wuxi People's Hospital · Zhejiang Provincial People's Hospital

Trials 33 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT04532203 Nov 2020 → Nov 2023 overdue acute lymphoblastic leukemia Zhejiang University Recruiting No outcome recorded
Phase 115 trials
Phase 1 NCT05828212 May 2023 → Jul 2025 neuromyelitis optica Zhejiang University Completed No outcome recorded
Phase 1 NCT05779917 Mar 2023 → Mar 2029 expected malignant pancreatic neoplasm Second Affiliated Hospital of Guangzhou Medical University Recruiting No outcome recorded
Phase 1 NCT05268172 Dec 2022 → Dec 2024 pleural neoplasm Affiliated Hospital of Jiangnan University Unknown No outcome recorded
Phase 1 NCT05420493 Sep 2021 → Sep 2024 non-Hodgkin lymphoma Chongqing Precision Biotech Co., Ltd Unknown No outcome recorded
Phase 1 NCT04863066 May 2021 → Jun 2022 Beijing 302 Hospital Unknown No outcome recorded
Phase 1 NCT04766840 Mar 2021 → Jun 2023 acute myeloid leukemia Beijing Immunochina Medical Science & Technology Co., Ltd. Unknown No outcome recorded
Phase 1 NCT05063682 May 2020 → Oct 2023 glioblastoma Chembrain LTD Unknown No outcome recorded
Phase 1 NCT03881774 Feb 2019 → Jan 2021 B-cell non-Hodgkin lymphoma Henan Cancer Hospital Unknown No outcome recorded
Phase 1 NCT03767725 Jun 2018 → Jun 2021 plasma cell myeloma Shenzhen Second People's Hospital Unknown No outcome recorded
Phase 1 NCT03283631 May 2018 → Sep 2019 gliosarcoma Gary Archer Ph.D. Terminated No outcome recorded
Phase 1/28 trials
Phase 1/2 NCT03271632 Jun 2026 → Dec 2029 expected plasma cell myeloma Shenzhen Geno-Immune Medical Institute Recruiting No outcome recorded
Phase 1/2 NCT06429150 May 2024 → Jul 2027 expected plasma cell myeloma, plasmacytoma Shenzhen Geno-Immune Medical Institute Recruiting No outcome recorded
Phase 1/2 NCT06352281 Feb 2024 → Jan 2026 overdue autoimmune thrombocytopenia 920th Hospital of Joint Logistics Support Force of People's Liberation Army of China Recruiting No outcome recorded
Phase 1/2 NCT04790747 Mar 2021 → Mar 2024 hematopoietic and lymphoid cell neoplasm Zhejiang University Unknown No outcome recorded
Phase 1/2 NCT03525782 Feb 2018 → Jan 2021 non-small cell lung carcinoma The First Affiliated Hospital of Guangdong Pharmaceutical University Unknown No outcome recorded
Phase 1/2 NCT03312205 Aug 2017 → Aug 2019 leukemia, plasma cell myeloma Hebei Senlang Biotechnology Inc., Ltd. Unknown No outcome recorded
Phase 1/2 NCT03366324 May 2016 → Jan 2021 B-cell non-Hodgkin lymphoma, acute lymphoblastic leukemia Wuhan Sian Medical Technology Co., Ltd Unknown No outcome recorded
Phase 1/2 NCT02965092 Dec 2015 → Jan 2021 acute lymphoblastic leukemia Wuhan Sian Medical Technology Co., Ltd Unknown No outcome recorded
Phase 23 trials
Phase 2 NCT06698484 Jun 2021 → Jun 2025 overdue B-cell non-Hodgkin lymphoma National University of Malaysia Recruiting No outcome recorded
Phase 2 NCT03931421 Jul 2019 → Nov 2022 plasma cell myeloma First Affiliated Hospital of Zhejiang University Unknown No outcome recorded
Phase 2 NCT03068416 Sep 2017 → Aug 2021 lymphoid leukemia, lymphoma Uppsala University Completed No outcome recorded
Phase 32 trials
Phase 3 NCT07103668 Aug 2025 → May 2027 expected gastric adenocarcinoma Suzhou Immunofoco Biotechnology Co., Ltd Recruiting No outcome recorded
Phase 3 NCT06904729 May 2025 → Apr 2029 expected lupus nephritis Guangzhou Women and Children's Medical Center Recruiting No outcome recorded
Phase not applicable3 trials
NCT06849921 Nov 2024 → Dec 2030 expected hematologic disorder Ruijin Hospital Active not recruiting No outcome recorded
NCT06481241 Jun 2024 → Jun 2026 overdue adult acute lymphoblastic leukemia Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded
NCT06481228 Jun 2024 → Jun 2026 overdue adult acute lymphoblastic leukemia, precursor B-cell acute lymphoblastic leukemia Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded
Phase not stated1 trial
NCT04008524 hematopoietic and lymphoid cell neoplasm Institute of Hematology & Blood Diseases Hospital, China Available No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 35 sources stand behind the page.

FieldValueCited text
Known as CAR-T cells “Subjects will receive (0.6-60)x10E8 transduced CART cells as a split dose over three days as follows: Day 0, 10% fraction: (0.06-6)x10E8 CART19 cells, Day 1, 30% fraction:...” NCT03767725
27

“a novel method for treatment of multiple myeloma, in which patients' T cells are engineered into B Cell Maturation Antigen(BMCA)-Targeted CAR-T cells to eliminate myeloma cells.” NCT03931421

“This intervention involves the infusion of autologous or allogeneic CAR-T cells into patients with relapsed/refractory hematologic malignancies.” NCT06849921

NCT03068416

NCT03198052

NCT04790747

NCT07103668

NCT02186860

NCT05420493

NCT03240328

NCT06698484

NCT06429150

NCT06352281

NCT04766840

NCT03881774

NCT06904729

NCT06481228

NCT05268172

NCT03312205

NCT03525782

NCT04863066

NCT04532203

NCT04008524

NCT02917083

NCT06481241

NCT05828212

NCT03271632

NCT05779917

Known as CAR gene-modified T cells “The name of the drug is CAR gene-modified T cells or abbreviated as EGFRvIII CARs.” NCT02664363
Known as EGFRvIII-CAR T Cells “The Efficacy and Safety of Brain-targeting Immune Cells (EGFRvIII-CAR T Cells) in Treating Patients With Leptomeningeal Disease From Glioblastoma.” NCT05063682
Known as EGFRvIII-CARs ClinicalTrials.gov intervention name — accepted as the source's own label NCT03283631
Known as Second generation CAR-T cells ClinicalTrials.gov intervention name — accepted as the source's own label NCT03366324
1

NCT02965092

Action Deplete “The trained cells are called CD30.CAR T cells. Then, the cells will be tested to make sure that they kill lymphoma cells that express the CD30 antigen and not normal cells.” NCT02917083
Modality Cell therapy “chimeric antigen receptor (CAR)-modified T cells” NCT02186860
Route Intravenous “a single dose of 1 million CAR-T cells per kg will be administrated intravenously” PMID 28039295 Dec 2016
Target CD19 “Chimeric antigen receptor T (CAR-T) cells targeting CD19PMID 35799791 Jun 2022