Drugs / WT1-Sensitized Allogeneic T-Lymphocytes
last change Mar 2020 re-read 2 minutes ago

WT1-Sensitized Allogeneic T-Lymphocytes

also known as TTCR-C4

targets WT1

Developed for
childhood acute myeloid leukemia · therapy related acute myeloid leukemia and myelodysplastic syndrome
Investigated by
Fred Hutchinson Cancer Center · National Cancer Institute (NCI)

Trials 1 · a red edge is where a trial was stopped

201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/2 NCT01640301 Dec 2012 → Mar 2020 MHC class I deficiency 2, childhood acute myeloid leukemia, disease related to hematopoietic stem cell transplant, therapy related acute myeloid leukemia and myelodysplastic syndrome Fred Hutchinson Cancer Center Terminated No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as WT1-Sensitized Allogeneic T-Lymphocytes ClinicalTrials.gov intervention name — accepted as the source's own label NCT01640301
Known as TTCR-C4 “inserted TCRC4 into Epstein-Bar virus-specific donor CD8+ T cells (TTCR-C4)” PMID 31235963 Jun 2019
Route Intravenous “WT1-sensitized T cells intravenously (IV)” NCT01640301
Target WT1 “Wilms tumor 1 (WT1)-specific T cell receptor” NCT01640301