Drugs / AXL1717
AXL1717
also known as
NSC-36407 · Picropodophyllin · Picropodophyllotoxin · Podophyllotoxin picropodophyllin
Small molecule targets IGF1R via inhibition
Trials 5
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 13 trials | ||||||
| Phase 1 | NCT01725555 | Oct 2012 → Dec 2013 | cancer, hematopoietic and lymphoid cell neoplasm | Axelar AB | Completed | No outcome recorded |
| Phase 1 | NCT01466647 | Jan 2011 → Sep 2012 | non-small cell lung carcinoma | Axelar AB | Completed | No outcome recorded |
| Phase 1 | NCT01062620 | Apr 2008 → May 2011 | cancer | Axelar AB | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT01721577 | Dec 2012 → Dec 2015 | anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligoastrocytoma, anaplastic oligodendroglioma +1 | Rush University Medical Center | Terminated | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT01561456 | Dec 2011 → Dec 2013 | lung adenocarcinoma, squamous cell carcinoma | Axelar AB | Completed | No outcome recorded |
Evidence & citations 9 cited values
Every value below carries the sentence it was read from. 7 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | AXL1717 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01721577 ↗ |
| Known as | NSC-36407 | ChEMBL registry synonym — accepted as the source's own label CHEMBL283120 ↗ |
| Known as | Picropodophyllin | ChEMBL registry synonym — accepted as the source's own label CHEMBL283120 ↗ |
| Known as | Picropodophyllotoxin | ChEMBL registry synonym — accepted as the source's own label CHEMBL283120 ↗ |
| Known as | Podophyllotoxin picropodophyllin | ChEMBL registry synonym — accepted as the source's own label CHEMBL283120 ↗ |
| Action | Inhibit | “IGF-1 receptor inhibitor AXL1717” NCT01062620 ↗ |
| Modality | Small molecule | “oral small molecule insulin-like growth factor-1-receptor pathway modulator AXL1717” PMID 26161618 ↗ Jul 2015 |
| Route | Oral | “oral small molecule insulin-like growth factor-1-receptor pathway modulator AXL1717” PMID 26161618 ↗ Jul 2015 |
| Target | IGF1R | “IGF-1 receptor inhibitor AXL1717” NCT01062620 ↗ |