Drugs / CNS10-NPC-GDNF
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CNS10-NPC-GDNF

Cell therapy

Developed for
amyotrophic lateral sclerosis
Investigated by
California Institute for Regenerative Medicine (CIRM) · Cedars-Sinai Medical Center

Trials 2

20172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT05306457 May 2022 → Oct 2026 expected amyotrophic lateral sclerosis Cedars-Sinai Medical Center Active not recruiting No outcome recorded
Phase 1 NCT02943850 Apr 2017 → Oct 2019 amyotrophic lateral sclerosis Cedars-Sinai Medical Center Completed Met primary

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as CNS10-NPC-GDNF “human neural progenitor cells transduced with GDNF (CNS10-NPC-GDNF) differentiated to astrocytes protected spinal motor neurons and were safe in animal models.” PMID 36064599 ↗ Sep 2022
1

NCT05306457 ↗

Modality Cell therapy “human neural progenitor cells transduced with GDNF” PMID 36064599 ↗ Sep 2022
Route Other “CNS10-NPC-GDNF were transplanted unilaterally into the lumbar spinal cord” PMID 36064599 ↗ Sep 2022