Drugs / NKTR-262
last change May 2022 re-read 2 minutes ago

NKTR-262

Small molecule targets TLR7 via activation

Developed for
colorectal cancer · cutaneous neuroendocrine carcinoma · head and neck squamous cell carcinoma · melanoma · renal cell carcinoma · sarcoma · triple-negative breast carcinoma
Investigated by
Nektar Therapeutics

Trials 1 · a red edge is where a trial was stopped

201820192020202120222023202420252026
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/2 NCT03435640 Mar 2018 → May 2022 colorectal cancer, cutaneous neuroendocrine carcinoma, head and neck squamous cell carcinoma, melanoma +3 Nektar Therapeutics Terminated No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as NKTR-262 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03435640
Action Activate “NKTR-262 is a small molecule agonist of toll-like receptors (TLRs) 7/8” NCT03435640
Modality Small molecule “NKTR-262 is a small molecule agonist of toll-like receptors (TLRs) 7/8” NCT03435640
Route Other “intratumoral (IT) injections of NKTR-262” NCT03435640
Target TLR7 “NKTR-262 (TLR7/8 agonist) improves systemic antitumor CD8(+) T cell cytotoxicity” PMID 35444059 Apr 2022