Drugs / NEDISERTIB
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NEDISERTIB

also known as Peposertib · M3814 · MSC2490484A

Small molecule

Developed for
cancer · metastatic malignant neoplasm · acute myeloid leukemia · B-cell chronic lymphocytic leukemia · castration-resistant prostate carcinoma · childhood malignant neoplasm · cholangiocarcinoma · dedifferentiated liposarcoma
+32 more · endometrial endometrioid adenocarcinoma · fallopian tube carcinosarcoma · fallopian tube clear cell adenocarcinoma · fallopian tube endometrioid adenocarcinoma · fallopian tube mucinous adenocarcinoma · fallopian tube serous adenocarcinoma · fallopian tube transitional cell carcinoma · gallbladder carcinoma · gliosarcoma · hypopharynx squamous cell carcinoma · laryngeal squamous cell carcinoma · leiomyosarcoma · metastatic carcinoma in the bone · metastatic malignant neoplasm in the lymph nodes · myxofibrosarcoma · neuroendocrine neoplasm · oral cavity squamous cell carcinoma · oropharynx squamous cell carcinoma · ovarian carcinosarcoma · ovarian clear cell adenocarcinoma · ovarian endometrioid adenocarcinoma · ovarian mucinous adenocarcinoma · ovarian seromucinous carcinoma · ovarian serous adenocarcinoma · ovarian transitional cell carcinoma · pancreatic adenocarcinoma · primary peritoneal serous adenocarcinoma · renal cell carcinoma · small cell lung carcinoma · synovial sarcoma · undifferentiated ovarian carcinoma · undifferentiated pleomorphic sarcoma
Investigated by
National Cancer Institute (NCI) · Merck KGaA, Darmstadt, Germany · EMD Serono Research & Development Institute, Inc. · Fight Kids Cancer · Fondation ARC · Gustave Roussy, Cancer Campus, Grand Paris
+5 more · M.D. Anderson Cancer Center · Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany · NRG Oncology · National Cancer Institute, France · Telix Pharmaceuticals (Innovations) Pty Limited

Trials 18 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 113 trials
Phase 1 NCT05687136 Jun 2024 → Aug 2026 overdue metastatic malignant neoplasm National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1 NCT05711615 Feb 2024 → Nov 2026 expected dedifferentiated liposarcoma, leiomyosarcoma, myxofibrosarcoma, synovial sarcoma +1 National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1 NCT05868174 May 2023 → Dec 2024 overdue renal cell carcinoma Telix Pharmaceuticals (Innovations) Pty Limited Recruiting No outcome recorded
Phase 1 NCT04533750 Dec 2021 → Dec 2025 overdue hypopharynx squamous cell carcinoma, laryngeal squamous cell carcinoma, oral cavity squamous cell carcinoma, oropharynx squamous cell carcinoma National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1 NCT04750954 Jul 2021 → Dec 2026 expected neuroendocrine neoplasm National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1 NCT04702698 Jan → Mar 2021 Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 1 NCT04555577 Sep 2020 → Dec 2027 expected gliosarcoma M.D. Anderson Cancer Center Active not recruiting No outcome recorded
Phase 1 NCT04092270 May 2020 → Feb 2026 overdue endometrial endometrioid adenocarcinoma, fallopian tube carcinosarcoma, fallopian tube clear cell adenocarcinoma, fallopian tube endometrioid adenocarcinoma +12 National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1 NCT03983824 May 2020 → Jun 2027 expected acute myeloid leukemia National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1 NCT03724890 Nov 2018 → Sep 2021 cancer EMD Serono Research & Development Institute, Inc. Completed No outcome recorded
Phase 1/25 trials
Phase 1/2 NCT04172532 Jan 2021 → Aug 2026 overdue pancreatic adenocarcinoma National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1/2 NCT04071236 Oct 2020 → Apr 2027 castration-resistant prostate carcinoma, metastatic carcinoma in the bone, metastatic malignant neoplasm in the lymph nodes National Cancer Institute (NCI) Suspended No outcome recorded
Phase 1/2 NCT04068194 Apr 2020 → Jul 2027 expected cholangiocarcinoma, gallbladder carcinoma, metastatic malignant neoplasm National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1/2 NCT03770689 Mar 2019 → Jun 2021 EMD Serono Research & Development Institute, Inc. Completed No outcome recorded
Phase 1/2 NCT02813135 Aug 2016 → Feb 2031 expected childhood malignant neoplasm Gustave Roussy, Cancer Campus, Grand Paris Recruiting No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 19 sources stand behind the page.

FieldValueCited text
Known as NEDISERTIB ChEMBL registry synonym — accepted as the source's own label CHEMBL4297629
Known as M3814 “Participants received M3814 PiC or hot melt extrusion (HME) tablet orally once daily in combination with etoposide (intravenously) and cisplatin for 6 cycles with each cycle...” NCT03116971
2

NCT03724890

NCT02516813

Known as MSC2490484A ClinicalTrials.gov intervention name — accepted as the source's own label NCT02316197
Known as Peposertib ClinicalTrials.gov intervention name — accepted as the source's own label NCT04092270
13

NCT04071236

NCT03770689

NCT04702698

NCT02813135

NCT04750954

NCT04172532

NCT04555577

NCT05687136

NCT04533750

NCT05868174

NCT04068194

NCT05711615

NCT03983824

Action Inhibit “an Inhibitor of a DNA-dependent Protein Kinase” NCT02516813
Modality Small molecule CHEMBL4297629
Route Oral “Participants received MSC2490484A capsules 100 milligram (mg) orally, once daily (QD) from Day 1 to Day 21 of each treatment cycle until disease progression, unacceptable...” NCT02316197