Drugs / camicinal
last change Dec 2017 re-read 9 days ago

camicinal

also known as GSK962040 · GSK-962040B

Small molecule targets MLNR via activation

Developed for
gastroparesis
Investigated by
GlaxoSmithKline

Trials 11

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT01366560 Aug → Oct 2010 intestinal motility disease GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT01267071 Jun → Sep 2010 gastroparesis GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT01039974 Sep → Nov 2009 gastroparesis GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT00733551 Sep 2008 → Jul 2009 gastroparesis GlaxoSmithKline Completed No outcome recorded
Phase 1 NCT00562848 Sep 2007 → Jun 2008 gastroparesis GlaxoSmithKline Completed No outcome recorded
Phase 26 trials · 1 met primary · 2 missed
Phase 2 NCT02210000 Aug 2014 → Aug 2015 gastroparesis GlaxoSmithKline Completed Missed primary
Phase 2 NCT01934192 Apr 2014 → Jul 2016 gastroparesis GlaxoSmithKline Terminated Missed primary
Phase 2 NCT01602549 Jul 2012 → May 2014 gastroparesis GlaxoSmithKline Completed No outcome recorded
Phase 2 NCT01262898 May 2011 → Feb 2013 gastroparesis GlaxoSmithKline Completed No outcome recorded
Phase 2 NCT01039805 Dec 2009 → Jul 2011 gastroparesis GlaxoSmithKline Completed No outcome recorded
Phase 2 NCT00861809 Jun 2009 → Nov 2010 gastroparesis GlaxoSmithKline Completed Met primary

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 14 sources stand behind the page.

FieldValueCited text
Known as camicinal “We evaluated the effect of camicinal (GSK962040), a gastroprokinetic, on the absorption of l-dopa and symptoms of PD.” PMID 29278279 ↗ Dec 2017
3

“the novel gastric promotility agent motilin agonist camicinal (GSK962040) in critically ill feed-intolerant patients” PMID 27476581 ↗ Aug 2016

“Manometric evaluation of the motilin receptor agonist camicinal (GSK962040) in humans.” PMID 28782145 ↗ Aug 2017

NCT02210000 ↗

Known as GSK-962040B ChEMBL registry synonym — accepted as the source's own label CHEMBL489095 ↗
Known as GSK962040 “GSK962040 is a selective non-peptide motilin receptor agonist which is being developed for the treatment of conditions associated with slow rates of gastric emptying.” NCT01267071 ↗
9

“the novel gastric promotility agent motilin agonist camicinal (GSK962040) in critically ill feed-intolerant patients” PMID 27476581 ↗ Aug 2016

“GSK962040 is a selective non-peptide motilin receptor agonist” NCT01366560 ↗

NCT00562848 ↗

NCT00733551 ↗

NCT01039974 ↗

NCT00861809 ↗

NCT01602549 ↗

NCT01262898 ↗

NCT01934192 ↗

Action Activate “Camicinal (GSK962040), a small molecule motilin receptor agonist” PMID 28782145 ↗ Aug 2017
1

“Motilin receptor agonist” CHEMBL489095 ↗

Modality Small molecule “Camicinal (GSK962040), a small molecule motilin receptor agonist, has been shown to increase gastrointestinal motility.” PMID 28782145 ↗ Aug 2017
Route Oral “the Oral Motilin Receptor Agonist GSK962040” NCT00562848 ↗
Target MLNR “Motilin receptor agonist” CHEMBL489095 ↗