Drugs / PROTIRELIN
PROTIRELIN
also known as
Thyrotropin Releasing Hormone · TRH · 5-oxo-pro-his-pro-nh2 · A-38579 · ABBOTT-38579 · Lopremone · NSC-760113 · Protirelin tartrate · +11 more
Protein / enzyme biologic targets TRHR via activation
Trials 4
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 22 trials | ||||||
| Phase 2 | NCT00790296 | Dec 2006 → Feb 2010 | myalgic encephalomeyelitis/chronic fatigue syndrome | UConn Health | Terminated | No outcome recorded |
| Phase 2 | NCT00054756 | Feb 2003 → Sep 2014 | pituitary gland disorder, thyroid gland disorder | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT00004778 | Aug 1993 → ? | newborn respiratory distress syndrome | National Center for Research Resources (NCRR) | Completed | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT00004840 | May → Jun 1998 | respiratory distress syndrome in premature infants | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Completed | No outcome recorded |
| Comparator or background therapy1 trial | ||||||
| — | NCT02399475 Background | Jan 2015 → Sep 2019 | hypothyroidism | University of Pennsylvania | Completed | No outcome recorded |
Evidence & citations 25 cited values
Every value below carries the sentence it was read from. 6 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | PROTIRELIN | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | 5-oxo-pro-his-pro-nh2 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | A-38579 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | ABBOTT-38579 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | Lopremone | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | NSC-760113 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | Protirelin tartrate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | Protirelin, synthetic | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | Protirelina | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | Protireline | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | Relefact trh | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | SYNTHETIC TRH | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | Thypinone | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | Thyrel trh | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | Thyroid releasing hormone | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | Thyroliberin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | Thyrotropin Releasing Hormone | “TRH (Thyrotropin Releasing Hormone)” NCT00054756 ↗ |
| Known as | Thyrotropin-releasing factor | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Known as | TRH | “intravenous thyrotropin-releasing hormone (TRH)” NCT00004778 ↗ |
| Known as | Trh-cambridge | ChEMBL registry synonym — accepted as the source's own label CHEMBL1472 ↗ |
| Action | Activate | “Thyrotropin-releasing hormone receptor agonist” CHEMBL1472 ↗ |
| Modality | Peptide | “TRH is a neuropeptide used in the diagnostic evaluation of patients with dysfunction of the hypothalamic-pituitary-thyroid (HPT) axis.” NCT00054756 ↗ |
| Modality | Protein / enzyme biologic | — CHEMBL1472 ↗ |
| Route | Intravenous | “intravenous thyrotropin-releasing hormone (TRH)” NCT00004778 ↗ |
| Target | TRHR | “Thyrotropin-releasing hormone receptor agonist” CHEMBL1472 ↗ |