Drugs / Dapoxetine
Dapoxetine
also known as
Dapoxetina · Dapoxetine (as hydrochloride) · dapoxetine HCl · Dapoxetine Hydrochloride · Kutub · LY-210448 · LY210448 HCL · Priligy
Small molecule targets SLC6A4 via inhibition
Trials 18 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 14 trials | ||||||
| Phase 1 | NCT02485041 | Nov → Dec 2014 | — | SK Chemicals Co., Ltd. | Completed | No outcome recorded |
| Phase 1 | NCT02485028 | Oct → Nov 2013 | — | SK Chemicals Co., Ltd. | Completed | No outcome recorded |
| Phase 1 | NCT01928563 | Sep → Dec 2013 | — | Dong-A Pharmaceutical Co., Ltd. | Unknown | No outcome recorded |
| Phase 1 | NCT01366664 | Apr 2011 → Apr 2012 | premature ejaculation | Janssen Research & Development, LLC | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT01419470 | Feb 2011 → May 2012 | premature ejaculation | Yuhan Corporation | Completed | No outcome recorded |
| Phase 310 trials | ||||||
| Phase 3 | NCT06425224 | Jun 2022 → Jun 2025 overdue | premature ejaculation, toxic epidermal necrolysis | Boston Medical Group | Recruiting | No outcome recorded |
| Phase 3 | NCT04361305 | Jun 2020 → Jan 2021 | erectile dysfunction, premature ejaculation | Yan-Ping Huang | Unknown | No outcome recorded |
| Phase 3 | NCT01063881 | May 2010 → Jun 2011 | physiological sexual disorder | Janssen Research & Development, LLC | Completed | No outcome recorded |
| Phase 3 | NCT01063855 | Apr 2010 → Aug 2011 | erectile dysfunction, sexual disorder | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Completed | No outcome recorded |
| Phase 3 | NCT00210704 | Mar 2005 → Jun 2006 | erectile dysfunction | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Completed | No outcome recorded |
| Phase 3 | NCT00229073 | Dec 2004 → Oct 2006 | erectile dysfunction | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Completed | No outcome recorded |
| Phase 3 | NCT00210613 | Nov 2004 → Aug 2005 | premature ejaculation | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Completed | No outcome recorded |
| Phase 3 | NCT00211107 | Jun 2003 → Jun 2004 | premature ejaculation | Alza Corporation | Completed | No outcome recorded |
| Phase 3 | NCT01230762 | ? → Apr 2005 | erectile dysfunction, premature ejaculation | Alza Corporation | Completed | No outcome recorded |
| Phase 3 | NCT00211094 | ? → Jun 2004 | premature ejaculation | Alza Corporation | Completed | No outcome recorded |
| Phase 42 trials | ||||||
| Phase 4 | NCT03177746 | Dec 2022 → Jan 2023 | erectile dysfunction, premature ejaculation | Neutec Ar-Ge San ve Tic A.Ş | Unknown | No outcome recorded |
| Phase 4 | NCT02939495 | Oct 2016 → Jun 2017 | erectile dysfunction, premature ejaculation | Neutec Ar-Ge San ve Tic A.Ş | Completed | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT07067970 | Oct 2025 → Oct 2026 expected | premature ejaculation | Medipol University | Not yet recruiting | No outcome recorded |
Also used as a comparator or background therapy in 8 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT04850703 Comparator | Feb 2021 → May 2022 | premature ejaculation | Moises Domingo | Completed | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT05556083 Comparator | Oct 2022 → Sep 2023 | premature ejaculation | Al-Azhar University | Unknown | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT07081659 Comparator | Mar 2024 | premature ejaculation | Benha University | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT04085354 Comparator | Feb → Jun 2019 | premature ejaculation | Sohag University | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT07113145 Comparator | Jun 2024 → Jan 2025 | premature ejaculation | Beni-Suef University | Completed | No outcome recorded |
| Phase not applicable3 trials | ||||||
| — | NCT06451406 Comparator | Oct 2022 → Jun 2023 | — | New Valley University | Completed | No outcome recorded |
| — | NCT03583112 Comparator | Jul → Dec 2018 | premature ejaculation | Xidian University | Unknown | No outcome recorded |
| — | NCT02844998 Comparator | Jan 2015 → May 2016 | premature ejaculation | Ankara Training and Research Hospital | Completed | No outcome recorded |
Evidence & citations 13 cited values
Every value below carries the sentence it was read from. 28 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Dapoxetine | “The medical records of all adult males suffering from mono-symptomatic premature ejaculation who were treated with on demand dapoxetine for 2 months with no improvement and...” NCT05556083 ↗25“Study drugs used will be terazosin (a drug given for the treatment of hypertension and benign prostatic hyperplasia) and dapoxetine (a new drug being studied for the treatment...” NCT01366664 ↗ “The aim of this study was to compare the effectiveness and safety of selective serotonin reuptake inhibitors (dapoxetine) and hyaluronic acid gel injection in the glans penis...” NCT06451406 ↗ “This study aims to compare the efficacy and safety of dapoxetine, Kegel exercises, acupuncture, and their placebo controls in the treatment of premature ejaculation (PE).” NCT07067970 ↗ “Received Dapoxetine hydrochloride 30 mg, administered daily.” NCT07113145 ↗ |
| Known as | Dapoxetina | ChEMBL registry synonym — accepted as the source's own label CHEMBL2110900 ↗ |
| Known as | Dapoxetine (as hydrochloride) | ChEMBL registry synonym — accepted as the source's own label CHEMBL2110900 ↗ |
| Known as | dapoxetine HCl | “A Placebo-Controlled, Double-blind, Randomized, Parallel Study of the Efficacy and Safety of Dapoxetine HCl in the Treatment of Rapid Ejaculation” NCT00211094 ↗ |
| Known as | Dapoxetine Hydrochloride | “Dapoxetine Hydrochloride Tablet” NCT03583112 ↗ |
| Known as | Kutub | ChEMBL registry synonym — accepted as the source's own label CHEMBL2110900 ↗ |
| Known as | LY-210448 | ChEMBL registry synonym — accepted as the source's own label CHEMBL2110900 ↗ |
| Known as | LY210448 HCL | ChEMBL registry synonym — accepted as the source's own label CHEMBL2110900 ↗ |
| Known as | Priligy | ChEMBL registry synonym — accepted as the source's own label CHEMBL2110900 ↗ |
| Action | Inhibit | “Dapoxetine is a short-acting selective serotonin reuptake inhibitor” PMID 19878447 ↗ Oct 20091“Serotonin transporter inhibitor” CHEMBL2110900 ↗ |
| Modality | Small molecule | — CHEMBL2110900 ↗ |
| Route | Oral | “Oral tablets of dapoxetine (60 milligrams)” NCT00210613 ↗ |
| Target | SLC6A4 | “Serotonin transporter inhibitor” CHEMBL2110900 ↗ |