Drugs / N-butyl-2-cyanoacrylate
last change Apr 2026 re-read 9 days ago

N-butyl-2-cyanoacrylate

also known as Histoacryl · Histoacryl blue · PeriAcryl

Other / unclassified

Developed for
esophageal varices · esophageal varices with bleeding · gastric ulcer · liver disorder · varicose disease
Investigated by
Minia University · Beirut Arab University

Trials 4

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT07086482 Aug 2025 → Mar 2026 overdue — Beirut Arab University Recruiting No outcome recorded
Phase 11 trial
Phase 1 NCT07132541 Aug 2025 → Nov 2026 expected ampulla of vater cancer, malignant pancreatic neoplasm Minia University Recruiting No outcome recorded
Phase 21 trial
Phase 2 NCT07230509 Dec 2025 → Dec 2027 expected ampulla of vater cancer, malignant pancreatic neoplasm Minia University Recruiting No outcome recorded
Phase not applicable1 trial
— NCT07155525 Sep 2025 → Sep 2028 expected cholangiocarcinoma, pancreatic ductal adenocarcinoma, periampullary adenocarcinoma Minia University Recruiting No outcome recorded
Comparator or background therapy7 trials
Phase 3 NCT06106971 Comparator Jun 2018 → Jun 2025 liver disorder, varicose disease Kaohsiung Veterans General Hospital. Unknown No outcome recorded
Phase 3 NCT03388125 Comparator Jan 2016 → Aug 2017 esophageal varices with bleeding Tanta University Unknown No outcome recorded
Phase 3 NCT01717612 Comparator Oct 2012 → Apr 2016 esophageal varices, gastric ulcer National Science and Technology Council, Taiwan Unknown No outcome recorded
Phase 4 NCT00799851 Comparator Nov 2004 → May 2007 liver disorder Federal University of São Paulo Completed No outcome recorded
— NCT02468180 Comparator Jun 2015 → Jul 2022 — West China Hospital Unknown No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 12 sources stand behind the page.

FieldValueCited text
Known as N-Butyl-2 Cyanoacrylate “the injected agents consisted of n-butyl-2-cyanoacrylate (Histoacryl; B.Braun, Melsungen AG, Germany) 0.5ml mixed with 1.5 ml Lipiodol ultra-fluide (Guerbet, Bois Cedex, France).” NCT01717612 ↗
10

“Endoscopic injection sclerotherapy versus N-Butyl-2 Cyanoacrylate injection in the management of actively bleeding esophageal varices: a randomized controlled trial.” PMID 30717684 ↗ Feb 2019

“CI group received intravariceal injections of 0.5 ml of N-butyl-2-cyanoacrylate (Histoacryl®) diluted in 0.5 ml of Lipiodol (Lipiodol®).” NCT00799851 ↗

“Injection of Histoacryl® (n-butyl-2-cyanoacrylate) mixed with Lipiodol® (1:1 ratio) into the pancreatic parenchyma” NCT07230509 ↗

“Information of drug: N-butyl-2-cyanoacrylate Name: Histoacryl blue Manufacturer: Braun, Melsungen, Germany” NCT06106971 ↗

NCT07132541 ↗

NCT02468180 ↗

NCT07155525 ↗

NCT02468167 ↗

NCT02468206 ↗

NCT03388125 ↗

Known as Histoacryl “the injected agents consisted of n-butyl-2-cyanoacrylate (Histoacryl; B.Braun, Melsungen AG, Germany) 0.5ml mixed with 1.5 ml Lipiodol ultra-fluide (Guerbet, Bois Cedex, France).” NCT01717612 ↗
2

“CI group received intravariceal injections of 0.5 ml of N-butyl-2-cyanoacrylate (Histoacryl®) diluted in 0.5 ml of Lipiodol (Lipiodol®).” NCT00799851 ↗

“Injection of Histoacryl® (n-butyl-2-cyanoacrylate) mixed with Lipiodol® (1:1 ratio) into the pancreatic parenchyma” NCT07230509 ↗

Known as Histoacryl blue “N-butyl-2-cyanoacrylate Name: Histoacryl blue Manufacturer: Braun, Melsungen, Germany” NCT06106971 ↗
Known as PeriAcryl “The goal of this clinical trial is to learn if the use of cyanoacrylate glue (PeriAcryl) is effective in healing of the palatal donor site in adults requiring a free gingival graft.” NCT07086482 ↗
Modality Other / unclassified “N-butyl-2-cyanoacrylate is a biodegradable tissue adhesive” NCT07155525 ↗
Route Other “CI group received intravariceal injections” NCT00799851 ↗