Drugs / YL-13027
last change Sep 2025 re-read 2 minutes ago

YL-13027

Small molecule targets TGFBR1 via inhibition

Developed for
cancer · malignant pancreatic neoplasm
Investigated by
Shanghai YingLi Pharmaceutical Co. Ltd. · 280Bio, Inc. · M.D. Anderson Cancer Center · Yingli Pharma US, Inc

Trials 5 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT06199466 Jan 2024 → Sep 2025 malignant pancreatic neoplasm M.D. Anderson Cancer Center Terminated No outcome recorded
Phase 1 NCT05228600 May → Dec 2022 cancer Shanghai YingLi Pharmaceutical Co. Ltd. Unknown No outcome recorded
Phase 1 NCT03869632 Mar 2019 → Apr 2021 cancer Shanghai YingLi Pharmaceutical Co. Ltd. Unknown No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT06662669 Nov 2024 → Sep 2027 expected malignant pancreatic neoplasm Shanghai YingLi Pharmaceutical Co. Ltd. Not yet recruiting No outcome recorded
Phase 1/2 NCT05457517 Sep 2022 → Jun 2024 cancer Shanghai YingLi Pharmaceutical Co. Ltd. Unknown No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as YL-13027 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03869632
4

NCT05228600

NCT06662669

NCT05457517

NCT06199466

Action Inhibit inhibits protein serine/threonine kinase of activin receptor-like kinase 5 (ALK5)” NCT03869632
Modality Small molecule “YL-13027 is an orally bioavailable small moleculeNCT03869632
Route Oral “YL-13027 is given orally daily.” NCT03869632
Target TGFBR1 “YL-13027 is a novel small molecule TGF-βR1 inhibitor.” NCT05228600