Drugs / AAV-GAD
Trials 4
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT00195143 | Aug 2003 → Aug 2005 | Parkinson disease | Neurologix, Inc. | Completed | No outcome recorded |
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT05894343 | May 2023 → Oct 2029 expected | Parkinson disease | MeiraGTx, LLC | Active not recruiting | No outcome recorded |
| Phase 1/2 | NCT05603312 | Oct 2022 → Sep 2024 | Parkinson disease | MeiraGTx, LLC | Completed | No outcome recorded |
| Phase 21 trial · 1 met primary | ||||||
| Phase 2 | NCT00643890 | Aug 2008 → Dec 2010 | Parkinson disease | Neurologix, Inc. | Terminated | Met primary Stop: Business |
News releases announcing trial results or a regulatory action · 1
| Date | Issuer | Release |
|---|---|---|
| 2025-05-13 | MeiraGTx, LLC | Regulatory MeiraGTx Reports First Quarter 2025 Financial and Operational Results meiragtx.com ↗
U.S. Food and Drug Administration (FDA) Granted Regenerative Medicine Advanced Therapy (RMAT) designation for AAV-GAD for the treatment of Parkinson’s disease |
All press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2025-05-13 | MeiraGTx, LLC | MeiraGTx Reports First Quarter 2025 Financial and Operational Results meiragtx.com ↗ |
Evidence & citations 4 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | AAV-GAD | ClinicalTrials.gov intervention name — accepted as the source's own label NCT05603312 ↗ |
| Action | Restore | “introduce the gene for glutamic acid decarboxylase (GAD) into the STN using an adeno-associated virus (AAV) vector, in order to permit the STN to produce it's own GABA” NCT00195143 ↗ |
| Modality | Gene therapy (AAV / viral vector) | “gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease” PMID 17586305 ↗ Jun 2007 |
| Route | Other | “Surgical infusion of AAV-GAD into the subthalamic nucleus” NCT00195143 ↗ |