Drugs / SHR0302

Trials 38 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT04146207 Apr 2020 → Sep 2024 chronic graft versus host disease Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Completed No outcome recorded
Phase 112 trials
Phase 1 NCT07098117 Jun → Jul 2024 Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT06202612 Jan → Feb 2024 autoimmune disease Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT05900089 May 2023 → Nov 2025 peripheral T-cell lymphoma, not otherwise specified Henan Cancer Hospital Unknown No outcome recorded
Phase 1 NCT05856058 May → Jul 2023 graft versus host disease Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT05392127 Jul → Aug 2022 rheumatoid arthritis Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT05404724 Jun → Jul 2022 rheumatoid arthritis Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT05047341 Sep 2021 rheumatoid arthritis Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT04712838 Mar → Apr 2021 Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT04293029 May → Dec 2020 Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 1 NCT02892370 Aug → Sep 2016 rheumatoid arthritis Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT07641010 Jun 2026 → Sep 2028 expected Hodgkins lymphoma Shanghai Jiao Tong University School of Medicine Not yet recruiting No outcome recorded
Phase 1/2 NCT07381114 Feb → Dec 2026 expected acute graft versus host disease Institute of Hematology & Blood Diseases Hospital, China Not yet recruiting No outcome recorded
Phase 212 trials
Phase 2 NCT07634848 Jun 2026 → May 2027 Behcet disease Liu Tian Withdrawn No outcome recorded
Phase 2 NCT07505186 May 2026 → Dec 2028 expected esophageal squamous cell carcinoma Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded
Phase 2 NCT07570745 May 2026 → May 2028 expected acute graft versus host disease Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Recruiting No outcome recorded
Phase 2 NCT07324473 Jan 2026 → Jan 2028 expected hepatocellular carcinoma First Affiliated Hospital of Chongqing Medical University Not yet recruiting No outcome recorded
Phase 2 NCT07313202 Dec 2025 → Dec 2027 expected Fujian Cancer Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07251595 Dec 2025 → Mar 2027 expected vitiligo Jiangsu HengRui Medicine Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT06925048 Apr 2025 → Dec 2026 expected non-small cell lung carcinoma Chunxia Su Not yet recruiting No outcome recorded
Phase 2 NCT06731153 Dec 2024 → Jun 2027 expected triple-negative breast carcinoma Fudan University Not yet recruiting No outcome recorded
Phase 2 NCT06519526 Aug 2024 → Feb 2027 expected peripheral T-cell lymphoma, not otherwise specified Fudan University Recruiting No outcome recorded
Phase 2 NCT03677648 May 2019 → Sep 2021 Crohn disease Reistone Biopharma Company Limited Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT04481139 Oct 2020 → Nov 2022 ankylosing spondylitis Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 35 trials
Phase 3 NCT05324631 Aug 2022 → Aug 2024 spondyloarthropathy Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 3 NCT05181137 Nov 2021 → Oct 2024 ulcerative colitis Reistone Biopharma Company Limited Unknown No outcome recorded
Phase 3 NCT04957550 Aug 2021 → Nov 2024 psoriatic arthritis Jiangsu HengRui Medicine Co., Ltd. Unknown No outcome recorded
Phase 3 NCT04875169 Apr 2021 → Aug 2022 atopic eczema Reistone Biopharma Company Limited Completed No outcome recorded
Phase 3 NCT04333771 Jul 2020 → Jan 2023 rheumatoid arthritis Jiangsu HengRui Medicine Co., Ltd. Completed No outcome recorded
Phase 42 trials
Phase 4 NCT07451665 Apr 2026 → Mar 2029 expected Takayasu arteritis Chinese SLE Treatment And Research Group Not yet recruiting No outcome recorded
Phase 4 NCT07452445 Mar 2026 → Mar 2028 expected rheumatoid arthritis Tongji Hospital Not yet recruiting No outcome recorded
Phase not applicable3 trials
NCT07550452 Mar 2026 → Jun 2027 expected atopic eczema Peking University People's Hospital Not yet recruiting No outcome recorded
NCT07276620 Nov 2025 → Apr 2028 expected atopic eczema Xiangya Hospital of Central South University Not yet recruiting No outcome recorded
NCT07270003 Oct 2025 → Oct 2026 expected palmoplantar pustulosis Xijing Hospital Recruiting No outcome recorded
Also used as a comparator or background therapy in 6 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 22 trials
Phase 2 NCT04346316 Comparator May 2020 → Jun 2021 alopecia areata Reistone Biopharma Company Limited Completed No outcome recorded
Phase 2 NCT04162899 Comparator Nov 2019 → Aug 2020 atopic eczema Reistone Biopharma Company Limited Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT04717310 Comparator Dec 2020 → Sep 2023 atopic eczema Reistone Biopharma Company Limited Unknown No outcome recorded
Phase 2/3 NCT04774809 Comparator Jan 2020 → Mar 2022 vitiligo Reistone Biopharma Company Limited Terminated No outcome recorded
Phase 31 trial
Phase 3 NCT05470413 Comparator Apr 2022 → Oct 2023 alopecia areata Reistone Biopharma Company Limited Unknown No outcome recorded
Phase not applicable1 trial
NCT07266168 Comparator Jan 2026 → Dec 2027 expected polymyalgia rheumatica Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 46 sources stand behind the page.

FieldValueCited text
Known as SHR0302 “Ivarmacitinib (SHR0302) is a highly selective oral JAK1 inhibitor” NCT07570745
30

NCT03254966

NCT04333771

NCT07098117

NCT03675477

NCT03677648

NCT05181137

NCT07251595

NCT06202612

NCT04481139

NCT04162899

NCT05047341

NCT05404724

NCT04875169

NCT05324631

NCT04712838

NCT02665910

NCT05470413

NCT05392127

NCT06519526

NCT06925048

NCT04146207

NCT02892370

NCT05900089

NCT02423538

NCT04346316

NCT05856058

NCT04293029

NCT04774809

NCT04717310

NCT04957550

Known as Ivarmacitinib “A Prospective, Multicenter, Randomized Controlled Clinical Study of Camrelizumab in Combination With Ivarmacitinib as First-line Treatment for Pediatric Classical Hodgkin Lymphoma” NCT07641010
14

Ivarmacitinib (SHR0302), a selective Janus kinase 1 inhibitor” PMID 41357869 Nov 2025

NCT06731153

NCT07270003

NCT07505186

NCT07550452

NCT07634848

NCT07451665

NCT07381114

NCT07266168

NCT07313202

NCT07276620

NCT07452445

NCT07324473

NCT07570745

Action Inhibit “SHR0302 is a Janus kinase 1(JAK1) inhibitor, capable of blocking Janus kinase-signal transducer and activator of transcription (JAK-STATs) pathway and controlling inflammation.” NCT03675477
Modality Small molecule “Ivarmacitinib is a novel small-molecule targeted drug” NCT07452445
Route Oral “single ascending (SAD) oral doses of SHR0302” NCT02423538
Target JAK1 “A Novel JAK1 Inhibitor SHR0302 Combined With Prednisone for First-Line Treatment of Chronic Graft-versus-Host Disease: A Phase I Clinical Trial.” PMID 38798038 Jan 2024