Drugs / STP938
last change Jun 2025 re-read 3 minutes ago

STP938

also known as Dencatistat

Small molecule targets CTPS1 via inhibition

Developed for
B-cell non-Hodgkin lymphoma · cancer · essential thrombocythemia · T-cell non-Hodgkin lymphoma
Investigated by
Step Pharma, SAS

Trials 3

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT06297525 Aug 2024 → Dec 2026 expected cancer Step Pharma, SAS Recruiting No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT05463263 Aug 2022 → Dec 2026 expected B-cell non-Hodgkin lymphoma, T-cell non-Hodgkin lymphoma Step Pharma, SAS Recruiting No outcome recorded
Phase 21 trial
Phase 2 NCT06786234 Jun 2025 → Jun 2028 expected essential thrombocythemia Step Pharma, SAS Recruiting No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as STP938 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05463263 ↗
2

NCT06297525 ↗

NCT06786234 ↗

Known as Dencatistat “A Phase 2 Study to Assess STP938 (Dencatistat) as a Monotherapy in Adults With High Risk Essential Thrombocythaemia - The VECTRA Trial” NCT06786234 ↗
2

“A Phase 1/2 Study of STP938 (Dencatistat) for Adult Subjects With Relapsed/Refractory B-Cell and T-Cell Lymphomas” NCT05463263 ↗

“Study of STP938 (Dencatistat) in Advanced Solid Tumours” NCT06297525 ↗

Action Inhibit “The drug STP938 is an inhibitor of an enzyme called cytidine triphosphate synthase 1 (CTPS1).” NCT05463263 ↗
Modality Small molecule “Small molecule” NCT05463263 ↗
Route Oral “STP938 will be given as a tablet.” NCT05463263 ↗
Target CTPS1 “CTPS1 Inhibitor STP938” NCT06297525 ↗