Drugs / LABRADIMIL
last change Apr 2003 re-read 2 minutes ago

LABRADIMIL

also known as lobradimil · RMP-7

Protein / enzyme biologic targets BDKRB2 via activation

Developed for
central nervous system neoplasm · Cryptococcal meningitis · glioma · HIV infectious disease · medulloblastoma
Investigated by
National Cancer Institute (NCI) · Alkermes, Inc. · Children's Oncology Group

Trials 3 · a red edge is where a trial was stopped

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT00001502 Apr 1996 → Mar 2000 glioma, medulloblastoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT00002316 Cryptococcal meningitis, HIV infectious disease Alkermes, Inc. Completed No outcome recorded
Phase 21 trial
Phase 2 NCT00019422 Mar 1998 → Apr 2003 central nervous system neoplasm National Cancer Institute (NCI) Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as LABRADIMIL ChEMBL registry synonym — accepted as the source's own label CHEMBL2105864
Known as lobradimil ClinicalTrials.gov intervention name — accepted as the source's own label NCT00019422
1

NCT00002316

Known as RMP-7 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00001502
Action Activate “Bradykinin B2 receptor agonist” CHEMBL2105864
Modality Protein / enzyme biologic CHEMBL2105864
Route Intravenous “Patients receive carboplatin IV over 15 minutes and lobradimil IV over 10 minutes on days 1 and 2.” NCT00019422
Target BDKRB2 “Bradykinin B2 receptor agonist” CHEMBL2105864