Drugs / ZEN-3694

Trials 21 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT06102902 Jun 2024 → Jan 2027 colorectal adenocarcinoma National Cancer Institute (NCI) Suspended No outcome recorded
Phase 1 NCT06161493 Jan 2024 → Dec 2026 ovarian cancer Haider Mahdi Withdrawn No outcome recorded
Phase 1 NCT05950464 Dec 2023 → Jun 2027 expected endometrial clear cell adenocarcinoma, endometrial endometrioid adenocarcinoma, ovarian clear cell adenocarcinoma, ovarian endometrioid adenocarcinoma +1 National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1 NCT05803382 Nov 2023 → Jun 2027 expected colorectal carcinoma, metastatic malignant neoplasm National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1 NCT05372640 Aug 2023 → Jun 2027 expected female breast carcinoma, invasive breast carcinoma, metastatic malignant neoplasm, nut midline carcinoma National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1 NCT05422794 May 2023 → Mar 2027 expected female breast carcinoma, triple-negative breast carcinoma National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1 NCT05111561 Aug 2022 → Mar 2027 metastatic malignant neoplasm, triple-negative breast carcinoma National Cancer Institute (NCI) Suspended No outcome recorded
Phase 1 NCT04840589 Feb 2022 → Sep 2028 metastatic malignant neoplasm, ovarian carcinoma National Cancer Institute (NCI) Suspended No outcome recorded
Phase 1 NCT02705469 May 2016 → Oct 2017 castration-resistant prostate carcinoma Zenith Epigenetics Completed No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT05053971 Nov 2022 → Jul 2027 expected digestive system carcinoma, metastatic carcinoma, refractory malignant neoplasm National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1/2 NCT05019716 Jul 2022 → Jun 2026 overdue nut midline carcinoma National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1/2 NCT04145375 Nov 2019 → Dec 2027 expected castration-resistant prostate carcinoma Zenith Epigenetics Enrolling by invitation No outcome recorded
Phase 1/2 NCT02711956 Dec 2016 → Nov 2019 castration-resistant prostate carcinoma Zenith Epigenetics Completed No outcome recorded
Phase 28 trials
Phase 2 NCT05253131 Nov 2026 → Nov 2031 expected malignant peripheral nerve sheath tumor, neurofibromatosis type 1 University of Alabama at Birmingham Not yet recruiting No outcome recorded
Phase 2 NCT06922318 Aug 2025 → Aug 2031 expected castration-resistant prostate carcinoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting No outcome recorded
Phase 2 NCT05071937 Apr 2023 → Nov 2033 expected fallopian tube cancer, ovarian cancer, peritoneum cancer Alexander B Olawaiye, MD Recruiting No outcome recorded
Phase 2 NCT05327010 Nov 2022 → Dec 2026 expected metastatic malignant neoplasm National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 2 NCT05607108 Nov 2022 → Nov 2027 expected squamous cell lung carcinoma Memorial Sloan Kettering Cancer Center Recruiting No outcome recorded
Phase 2 NCT04986423 Sep 2021 → Dec 2026 expected castration-resistant prostate carcinoma Zenith Epigenetics Recruiting No outcome recorded
Phase 2 NCT04471974 Jan 2021 → May 2028 expected castration-resistant prostate carcinoma, prostate adenocarcinoma, prostate small cell carcinoma Rahul Aggarwal Active not recruiting No outcome recorded
Phase 2 NCT03901469 Jun 2019 → Mar 2024 triple-negative breast carcinoma Zenith Epigenetics Terminated No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 23 sources stand behind the page.

FieldValueCited text
Known as ZEN-3694 ClinicalTrials.gov intervention name — accepted as the source's own label NCT06102902
9

NCT05111561

NCT05950464

NCT05327010

NCT04471974

NCT05253131

NCT05372640

NCT05053971

NCT06922318

NCT04840589

Known as Bet bromodomain inhibitor zen-3694 ChEMBL registry synonym — accepted as the source's own label CHEMBL6068600
Known as ZEN003694 “This phase I trial tests the safety, side effects, and best dose of ZEN003694 in combination with cisplatin and etoposide or carboplatin and paclitaxel in treating patients...” NCT05019716
11

“A Phase 1 Study of ZEN003694 (ZEN-3694) in Combination With Cetuximab and Encorafenib in Patients With Refractory BRAF V600E Metastatic Colorectal Cancer” NCT06102902

ZEN003694 (ZEN-3694) With Pembrolizumab and Nab-paclitaxel in Patients With Metastatic Triple-Negative Breast Cancer” NCT05422794

ZEN003694 is an inhibitor of a family of proteins called the bromodomain and extra-terminal (BET).” NCT05803382

NCT05607108

NCT05071937

NCT03901469

NCT04145375

NCT02711956

NCT04986423

NCT06161493

NCT02705469

Action Inhibit “ZEN-3694 is an orally bioavailable small molecule BET inhibitor currently being evaluated in Phase 1/2 clinical trials (NCT03901469).” PMID 34385584 Aug 2021
Modality Small molecule “ZEN-3694 is an orally bioavailable small molecule BET inhibitor currently being evaluated in Phase 1/2 clinical trials (NCT03901469).” PMID 34385584 Aug 2021
Route Oral “ZEN003694 will be administered orally as a single agent once daily in 28-day cycles” NCT02705469
Target MYC “ZEN-3694 blocks the expression of the MYC gene” NCT04471974