Drugs / anti-CD19 CAR-T cells
Trials 22
News releases announcing trial results or a regulatory action · 1
| Date | Issuer | Release |
|---|---|---|
| 2021-12-10 | Caring Cross | Results Caring Cross Announces Publication in Nature Communications Demonstrating Effectiveness of Place-of-Care Manufacture of Anti-CD19 CAR T Cells for Treatment of B-cell Malignancies caringcross.org ↗
For NHL complete responders, the one-year survival rate was 92.9%, with a median duration of response yet to be reached. |
All press releases naming this drug 1 release
Evidence & citations 7 cited values
Every value below carries the sentence it was read from. 26 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | anti-CD19-CAR T-cells | “A single intravenous infusion of autologous anti-CD19 CAR-T cells will be administered on Day 0 at a target dose of 1 × 10⁶ CAR-T cells/kg.” NCT07493395 ↗22“The 10 treated patients received a single infusion of allogeneic anti-CD19-CAR T cells.” PMID 24055823 ↗ Sep 2013 “adoptive transfer of anti-CD19 CAR T cells is now being tested in clinical trials.” PMID 23546520 ↗ Apr 2013 |
| Known as | anti-CD19-CAR-transduced T cells | “These anti-CD19-CAR-transduced T cells specifically recognize a variety of CD19+ target cells and kill primary chronic lymphocytic leukemia (CLL) cells in vitro.” NCT01087294 ↗ |
| Known as | CD19 CAR T-cells | “For Biological: CD19 CAR T-cells” NCT06027957 ↗ |
| Action | Deplete | “anti-CD19-CAR-transduced T cells have great promise to improve the treatment of B-cell malignancies because of a potent ability to eradicate CD19(+) cells in vivo” PMID 22160384 ↗ Dec 2011 |
| Modality | Cell therapy | “adoptive transfer of anti-CD19 CAR T cells is now being tested in clinical trials.” PMID 23546520 ↗ Apr 2013 |
| Route | Intravenous | “Cells will be infused via intravenous (IV) on the Patient Care Unit over 20-30 minutes.” NCT00924326 ↗ |
| Target | CD19 | “We have constructed a retroviral vector that encodes an anti-cluster of differentiation 19 (CD19) chimeric antigen receptor (CAR) that recognizes the CD19 antigen.” NCT00924326 ↗ |