Drugs / AMG 208
last change Oct 2019 re-read 3 minutes ago

AMG 208

Small molecule targets MET via inhibition

Developed for
prostate cancer · neoplasm
Investigated by
Amgen · M.D. Anderson Cancer Center

Trials 2

2009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT00813384 Dec 2008 → Feb 2013 cancer Amgen Completed No outcome recorded
Phase 21 trial
Phase 2 NCT02420587 Oct 2014 → Oct 2019 prostate cancer M.D. Anderson Cancer Center Withdrawn No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as AMG 208 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00813384 ↗
1

NCT02420587 ↗

Action Inhibit “AMG 208 inhibits both ligand-dependent and ligand-independent c-Met cellular growth regulation.” NCT00813384 ↗
Modality Small molecule “AMG 208 is a small molecule inhibitor of c-Met” NCT00813384 ↗
Route Oral “Patients received AMG 208 orally on days 1 and days 4-28 once daily.” PMID 26155941 ↗ Jul 2015
Target MET “AMG 208 is a small molecule inhibitor of c-Met” NCT00813384 ↗