Drugs / Estradiol Cypionate
Estradiol Cypionate
also known as
Depo · Depo-estradiol · E2 cypionate · E2C · Estradiol 17.beta.-cyclopentanepropanoate · Estradiol cipionate · Estradiol cypionate component of depo-testadiol · Estradiol cypionate component of lunelle · +2 more
Small molecule targets ESR1 via activation
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | DEPO-ESTRADIOL | — | 1979-08-15 | fda.gov ↗ |
Trials 4
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT03443089 | Mar → Apr 2017 | — | Galeno Desenvolvimento de Pesquisas Clínicas | Completed | No outcome recorded |
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT03264781 | Aug 2016 → Dec 2017 | uterine disorder | Chulalongkorn University | Unknown | No outcome recorded |
| Phase 1/2 | NCT01699022 | Jun 2010 → Jul 2011 | — | Sun Pharmaceutical Industries, Inc. | Completed | No outcome recorded |
| Phase 21 trial · 1 missed | ||||||
| Phase 2 | NCT04865029 | Jul 2021 → Jan 2022 | COVID-19 | Tulane University | Terminated | Missed primary Stop: Enrollment |
Evidence & citations 15 cited values
Every value below carries the sentence it was read from. 8 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | estradiol cypionate | “Administration of a single intramuscular dose of an injectable formulation containing medroxyprogesterone acetate 25 mg/mL + estradiol cypionate 5 mg/mL after a” NCT03443089 ↗3“Cyclofem is a combined injectable contraceptive, containing medroxyprogesterone acetate (MPA) and estradiol cypionate.” PMID 23265980 ↗ Dec 2012 “Medroxyprogesterone Acetate 25 mg plus Estradiol Cypionate 5 mg (Cyclofem®) 0.5 ml IM injection single dose” NCT03264781 ↗ |
| Known as | Depo | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200973 ↗ |
| Known as | Depo-estradiol | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200973 ↗ |
| Known as | E2 cypionate | “E2 cypionate (5 mg, IM) and micronized P4 (200 mg, PO)” PMID 39349554 ↗ Sep 2024 |
| Known as | E2C | “Cyclofem® is a monthly injectable contraceptive containing 25 mg of medroxyprogesterone acetate (MPA) and 5 mg of estradiol cypionate (E2C), a long-acting ester of estradiol.” NCT01699022 ↗ |
| Known as | Estradiol 17.beta.-cyclopentanepropanoate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200973 ↗ |
| Known as | Estradiol cipionate | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200973 ↗ |
| Known as | Estradiol cypionate component of depo-testadiol | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200973 ↗ |
| Known as | Estradiol cypionate component of lunelle | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200973 ↗ |
| Known as | NSC-3354 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1200973 ↗ |
| Known as | Oestradiol cypionate | “Oestradiol cypionate intramuscular (IM) and micronised progesterone oral (PO), in addition to SOC” PMID 34848523 ↗ Nov 2021 |
| Action | Activate | “Estrogen receptor alpha agonist” CHEMBL1200973 ↗ |
| Modality | Small molecule | “The steroids estradiol (E2) and progesterone (P4) promote anti-inflammatory immune responses and their therapeutic use for COVID-19 has been under investigation.” PMID 39349554 ↗ Sep 2024 |
| Route | Other | “Women were administered three consecutive monthly injections of Cyclofem for prevention of ovulation” NCT01699022 ↗ |
| Target | ESR1 | “Estrogen receptor alpha agonist” CHEMBL1200973 ↗ |