Drugs / IMA203
last change Jul 2025 re-read 2 minutes ago

IMA203

Cell therapy targets PRAME

Developed for
cutaneous melanoma · refractory malignant neoplasm · synovial sarcoma
Investigated by
Immatics US, Inc. · ModernaTX, Inc.

Trials 3 · a red edge is where a trial was stopped

2020202120222023202420252026202720282029
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT06946225 Jul 2025 → Aug 2029 expected cutaneous melanoma, synovial sarcoma Immatics US, Inc. Recruiting No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT03686124 May 2019 → Dec 2028 expected refractory malignant neoplasm Immatics US, Inc. Recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT06743126 Jan 2025 → Jan 2028 expected cutaneous melanoma Immatics US, Inc. Recruiting No outcome recorded

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as IMA203 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03686124
2

NCT06743126

NCT06946225

Modality Cell therapy “IMA203, an autologous preferentially expressed antigen in melanoma (PRAME)-directed TCR T cell therapy in HLA-A*02+ patients with PRAME+ recurrent and/or refractory solid...” PMID 40205198 Apr 2025
Target PRAME “IMA203, an autologous preferentially expressed antigen in melanoma (PRAME)-directed TCR T cell therapy in HLA-A*02+ patients with PRAME+ recurrent and/or refractory solid...” PMID 40205198 Apr 2025