Drugs / HEC585
last change Oct 2025 re-read 9 days ago

HEC585

Small molecule

Developed for
idiopathic pulmonary fibrosis · interstitial lung disease
Investigated by
Sunshine Lake Pharma Co., Ltd.

Trials 8

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT05468346 Jul → Aug 2022 — Sunshine Lake Pharma Co., Ltd. Completed No outcome recorded
Phase 1 NCT07588646 Jun → Nov 2021 idiopathic pulmonary fibrosis Sunshine Lake Pharma Co., Ltd. Completed No outcome recorded
Phase 1 NCT05383131 Jun → Nov 2021 idiopathic pulmonary fibrosis Sunshine Lake Pharma Co., Ltd. Completed No outcome recorded
Phase 1 NCT04512170 Jul 2020 → Aug 2021 idiopathic pulmonary fibrosis Sunshine Lake Pharma Co., Ltd. Completed No outcome recorded
Phase 1 NCT03092102 May 2017 → Feb 2019 idiopathic pulmonary fibrosis Sunshine Lake Pharma Co., Ltd. Completed No outcome recorded
Phase 22 trials
Phase 2 NCT05139719 Feb 2023 → Dec 2026 expected interstitial lung disease Sunshine Lake Pharma Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT05060822 Jun 2021 → Jul 2025 overdue idiopathic pulmonary fibrosis Sunshine Lake Pharma Co., Ltd. Active not recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT07082842 Oct 2025 → Jan 2031 expected idiopathic pulmonary fibrosis Sunshine Lake Pharma Co., Ltd. Recruiting No outcome recorded

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2025-08-22 Sunshine Lake Pharma Co., Ltd. Results 东阳光药伊非尼酮II期临床取得积极结果,关键数据亮相2025第九届美国IPF峰会 hecpharm.com ↗
与安慰剂相比,作为衡量肺功能的重要指标,试验组各组在用药24周时均能延缓患者FVC下降,以 MMRM 模型敏感性分析结果显示,伊非尼酮200mg组较基线仅下降3.3 mL,相比较安慰剂组改善超过80mL,具有统计学意义(P<0.1),延缓下降的比例达96%,远优于同试验吡非尼酮组的47%。

All press releases naming this drug 1 release

DateIssuerRelease

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as HEC585 ClinicalTrials.gov intervention name — accepted as the source's own label NCT07082842 ↗
7

NCT07588646 ↗

NCT03092102 ↗

NCT05383131 ↗

NCT04512170 ↗

NCT05060822 ↗

NCT05468346 ↗

NCT05139719 ↗

Modality Small molecule “HEC585, a pyrimidone compound” NCT03092102 ↗
Route Oral “multiple oral dose” NCT03092102 ↗