Drugs / Elenbecestat
last change Jan 2020 re-read 2 minutes ago

Elenbecestat

also known as E2609

Small molecule targets BACE1 via inhibition

Developed for
Alzheimer disease
Investigated by
Eisai Inc. · Biogen

Trials 11 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT03055962 Feb → Mar 2017 Eisai Inc. Completed No outcome recorded
Phase 1 NCT02859207 Aug → Dec 2016 Alzheimer disease Eisai Inc. Completed No outcome recorded
Phase 1 NCT02222324 Aug → Oct 2014 Eisai Inc. Completed No outcome recorded
Phase 1 NCT02207790 Jul → Aug 2014 Eisai Inc. Completed No outcome recorded
Phase 1 NCT01975636 Jun → Nov 2013 Eisai Inc. Completed No outcome recorded
Phase 1 NCT01716897 Oct → Dec 2012 Alzheimer disease Eisai Inc. Completed No outcome recorded
Phase 1 NCT01600859 Jul 2012 → Sep 2013 Alzheimer disease Eisai Inc. Completed No outcome recorded
Phase 1 NCT01511783 Dec 2011 → Jul 2012 Eisai Inc. Completed No outcome recorded
Phase 1 NCT01294540 Dec 2010 → Oct 2011 Alzheimer disease Eisai Inc. Completed No outcome recorded
Phase 21 trial
Phase 2 NCT02322021 Nov 2014 → Dec 2019 Alzheimer disease Eisai Inc. Terminated No outcome recorded
Phase 31 trial
Phase 3 NCT02956486 Oct 2016 → Jan 2020 Alzheimer disease Eisai Inc. Terminated No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT02055703 Comparator Jan → Apr 2014 Eisai Inc. Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 13 sources stand behind the page.

FieldValueCited text
Known as Elenbecestat ClinicalTrials.gov intervention name — accepted as the source's own label NCT02956486
Known as E2609 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01716897
10

NCT02222324

NCT02055703

NCT02207790

NCT01294540

NCT01600859

NCT01975636

NCT01511783

NCT03055962

NCT02322021

NCT02859207

Action Inhibit “Beta-secretase 1 inhibitor” CHEMBL4204869
Modality Small molecule CHEMBL4204869
Route Oral “E2609 orally at varying ascending doses” NCT01294540
Target BACE1 “Beta-secretase 1 inhibitor” CHEMBL4204869