Drugs / Ad5.hAC6
Trials 2
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT00787059 | Jul 2010 → Jan 2015 | congestive heart failure | Hammond, H. Kirk, M.D. | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT03360448 | Jun 2019 → Jun 2020 | heart failure | Renova Therapeutics | Withdrawn | No outcome recorded Stop: Business |
News releases announcing trial results or a regulatory action · 2
| Date | Issuer | Release |
|---|---|---|
| 2017-04-11 | Renova Therapeutics | Results ‘Human Gene Therapy’ publishes review of randomized clinical trials of gene transfer for heart failure with reduced ejection fraction renovatherapeutics.com ↗
The review finds that, while efficacy varied among the clinical trials, gene transfer was not associated with an increased rate of adverse events, supporting further investigations using this treatment method in the HFrEF patient population. |
| 2016-03-30 | Renova Therapeutics | Results JAMA Cardiology publishes Phase 2 results of AC6 gene transfer in patients with heart failure renovatherapeutics.com ↗
Results indicate that, through a one-time administration, AC6 gene transfer safely increased heart function beyond optimal heart failure therapy. |
All press releases naming this drug 2 releases
| Date | Issuer | Release |
|---|---|---|
| 2017-04-11 | Renova Therapeutics | ‘Human Gene Therapy’ publishes review of randomized clinical trials of gene transfer for heart failure with reduced ejection fraction renovatherapeutics.com ↗ |
| 2016-03-30 | Renova Therapeutics | JAMA Cardiology publishes Phase 2 results of AC6 gene transfer in patients with heart failure renovatherapeutics.com ↗ |
Evidence & citations 1 cited value
Every value below carries the sentence it was read from. 2 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Ad5.hAC6 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03360448 ↗ |