broccoli sprout extract

also known as BSE · ITC-BSE

targets NQO1 via activation

Developed for: allergic respiratory disease · asthma · breast lobular carcinoma · chronic obstructive pulmonary disease · ductal breast carcinoma in situ · estrogen-receptor negative breast cancer · estrogen-receptor positive breast cancer · female breast carcinoma
+2 more
· invasive breast carcinoma · non-invasive bladder urothelial carcinoma
Investigated by: Johns Hopkins University · National Cancer Institute (NCI) · Roswell Park Cancer Institute · Breast Cancer Research Foundation · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · University of California, Los Angeles

2009201020112012201320142015201620172018201920202021202220232024202520262027

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 01 trial
Phase 0	NCT01753908	May 2013 → Jul 2018	breast lobular carcinoma, ductal breast carcinoma in situ, estrogen-receptor negative breast cancer, estrogen-receptor positive breast cancer +1	Roswell Park Cancer Institute	Completed	No outcome recorded
Phase 11 trial
Phase 1	NCT02592954	Sep 2015 → Dec 2016	epidermolysis bullosa simplex, pachyonychia congenita	Johns Hopkins University	Completed	No outcome recorded
Phase 21 trial · 1 missed
Phase 2	NCT00982319	Apr 2009 → Nov 2013	female breast carcinoma	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	Completed	Missed primary
Phase not applicable3 trials · 1 met primary
—	NCT01108003	Apr 2010 → Sep 2014	non-invasive bladder urothelial carcinoma	Roswell Park Cancer Institute	Terminated	No outcome recorded Stop: Enrollment
—	NCT00994604	Oct 2009 → Aug 2015	asthma, chronic obstructive pulmonary disease	Johns Hopkins University	Completed	No outcome recorded
—	NCT00882115	Jul 2009 → Dec 2011	allergic respiratory disease	University of California, Los Angeles	Completed	Met primary

Every value below carries the sentence it was read from. 7 sources stand behind the page.

Field	Value	Cited text
Known as	Broccoli Sprout Extract	ClinicalTrials.gov intervention name — accepted as the source's own label NCT01753908 ↗ 5 NCT00994604 ↗ NCT02592954 ↗ NCT00882115 ↗ NCT01108003 ↗ NCT00982319 ↗
Known as	BSE	“a standardized broccoli sprout extract (BSE), which contains a reproducible amount of the sulforaphane (SFN) precursor” PMID 24287881 ↗ Jan 2014 2 “Each participant will receive 7ml of broccoli sprout extract (BSE) in jojoba oil, containing 3500nmol of sulforaphane” NCT02592954 ↗ “broccoli sprout extract (BSE), rich in sulforaphane, improves airflow measures in asthmatics.” NCT00994604 ↗
Known as	ITC-BSE	“I. To determine whether isothiocyanate-rich broccoli sprout extract (ITC-BSE) modifies biomarkers in breast tumor cells.” NCT01753908 ↗
Action	Activate	“induces NAD(P)H dehydrogenase (quinone) 1 (NQO1) expression” NCT01753908 ↗
Route	Oral	“BSE will be ingested by drinking a liquid formula” NCT00882115 ↗
Target	NQO1	“induces NAD(P)H dehydrogenase (quinone) 1 (NQO1) expression” NCT01753908 ↗