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Drugs / Neutral protamine hagedorn insulin
last change Dec 2021 re-read 2 minutes ago

Neutral protamine hagedorn insulin

also known as human isophane insulin · isofane insulin · NPH

Protein / enzyme biologic

Developed for
type 2 diabetes mellitus · type 5 diabetes mellitus
Investigated by
Alkermes, Inc. · Eli Lilly and Company

Trials 1 · a red edge is where a trial was stopped

today NCT00490854 · Ph 2/3
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2/3 NCT00490854 Jul 2007 → May 2008 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 4 NCT04690309 Comparator Jul 2018 → Dec 2020 type 5 diabetes mellitus Polish Society of Diabetology Unknown No outcome recorded
Phase 4 NCT03389490 Comparator Jan 2018 → Dec 2019 type 2 diabetes mellitus Elaine Chow Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as Neutral Protamine Hagedorn insulin “with Neutral Protamine Hagedorn insulin (isofane insulin) administered subcutaneously before sleep” NCT04690309 ↗
2

NCT00490854 ↗

NCT03389490 ↗
Known as human isophane insulin “NPH (neutral protamine Hagedorn) insulin (human isophane insulin)” PMID 33166419 ↗ Nov 2020
Known as isofane insulin “with Neutral Protamine Hagedorn insulin (isofane insulin) administered subcutaneously before sleep” NCT04690309 ↗
Known as NPH “patient-adjusted titration of Gla-300 (n = 23) versus NPH (n = 23) at bedtime in insulin-naïve T2D patients” PMID 33738774 ↗ Mar 2021
Modality Protein / enzyme biologic “NPH (neutral protamine Hagedorn) insulin (human isophane insulin)” PMID 33166419 ↗ Nov 2020
Route Other “patient specific dose, injected, daily, 76 weeks” NCT00490854 ↗