Drugs / β-hydroxy-β-methylbutyrate
last change Aug 2026 re-read 2 minutes ago

β-hydroxy-β-methylbutyrate

also known as HMB

targets IGFBP7 via inhibition

Developed for
amyotrophic lateral sclerosis
Investigated by
Duke University · Medical College of Wisconsin · Temple University

Trials 2 · a red edge is where a trial was stopped

20142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT07589764 Jul 2026 overdue amyotrophic lateral sclerosis Duke University Not yet recruiting No outcome recorded
Phase 21 trial
Phase 2 NCT01607879 Mar 2014 → Jul 2018 prostate cancer Medical College of Wisconsin Completed No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as β-hydroxy-β-methylbutyrate “Use of β-hydroxy-β-methylbutyrate to Counteract Muscle Loss in Men With Prostate Cancer on Androgen Ablation” NCT01607879
1

NCT07589764

Known as HMB “β-hydroxy-β-methylbutyrate (HMB)” NCT07589764
Action Inhibit “to lower insulin-like growth-factor binding protein 7 (IGFBP7)” NCT07589764
Target IGFBP7 “ability to lower insulin-like growth-factor binding protein 7 (IGFBP7)” NCT07589764