Drugs / GSK189254
last change Jan 2008 re-read 9 days ago

GSK189254

also known as [11C]GSK-189254

Small molecule targets HRH3 via inhibition

Developed for
narcolepsy
Investigated by
GlaxoSmithKline

Trials 2

200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT00387413 Oct 2006 → May 2007 — GlaxoSmithKline Completed No outcome recorded
Phase 21 trial
Phase 2 NCT00366080 Nov 2006 → Jan 2008 narcolepsy GlaxoSmithKline Terminated No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as GSK189254 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00366080 ↗
1

NCT00387413 ↗

Known as [11C]GSK-189254 ChEMBL registry synonym — accepted as the source's own label CHEMBL517140 ↗
Action Inhibit “the Histamine H3 antagonist GSK189254” NCT00366080 ↗
1

“Histamine H3 receptor antagonist” CHEMBL517140 ↗

Modality Small molecule — CHEMBL517140 ↗
Route Oral “The effects of repeated oral dosing of GSK189254 and duloxetine on secondary hyperalgesia in the EH model will be determined.” NCT00387413 ↗
Target HRH3 “Histamine H3 receptor antagonist” CHEMBL517140 ↗