Drugs / CT327
last change Dec 2018 re-read 2 minutes ago

CT327

also known as Pegcantratinib · SNA-120 · Pegylated K-252

targets NGF via inhibition

Developed for
atopic eczema · psoriasis
Investigated by
Creabilis SA · Aalborg University Hospital · LCG Bioscience

Trials 5 · a red edge is where a trial was stopped

20082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT01243307 Jan → Apr 2011 neuropathy, painful Creabilis SA Completed No outcome recorded
Phase 1 NCT01243502 Sep → Nov 2007 Creabilis SA Completed No outcome recorded
Phase 1 NCT01368315 atopic eczema Creabilis SA Withdrawn No outcome recorded
Phase 22 trials
Phase 2 NCT01808157 Jul 2013 → Apr 2014 atopic eczema Creabilis SA Completed No outcome recorded
Phase 2 NCT01465282 Dec 2011 → Sep 2012 psoriasis Creabilis SA Completed No outcome recorded
Also used as a comparator or background therapy in 3 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT03448081 Comparator Feb → Nov 2018 psoriasis Sienna Biopharmaceuticals Completed No outcome recorded
Phase 2 NCT03322137 Comparator Oct 2017 → Sep 2018 psoriasis Sienna Biopharmaceuticals Completed No outcome recorded
Phase 2 NCT00996008 Comparator Nov 2009 → Oct 2010 atopic eczema Creabilis SA Terminated No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 8 sources stand behind the page.

FieldValueCited text
Known as CT 327 “Positive responders to the APT test will enter into a treatment period of ten days during which all subjects will have three test compounds (CT 327, Placebo or an active...” NCT01368315
6

NCT01368315

NCT01243307

NCT01465282

NCT00996008

NCT01808157

NCT01243502

Known as Pegcantratinib “SNA-120 (Pegcantratinib) Ointment” NCT03322137
1

“SNA-120 (Pegcantratinib) Ointment” NCT03448081

Known as Pegylated K-252 “A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Study of the Safety and Efficacy of CT 327, Pegylated K-252, Formulated as a Cream, When Administered...” NCT00996008
Known as SNA-120 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03322137
1

NCT03448081

Action Inhibit inhibitor of nerve growth factor (NGF)” NCT01243502
Route Topical “0.5 g CT 327 cream will be applied to 2 target lesions twice daily 0.5 g placebo cream will be applied to remaining 2 target lesions twice daily” NCT00996008
Target NGF “inhibitor of nerve growth factor (NGF)” NCT01243502