Drugs / ADENOVIRUS TYPE 26 ENCODING EBOLA VIRUS GLYCOPROTEIN

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Withdrawn EU (EMA) Zabdeno 2026-05-01 europa.eu
Approved EU (EMA) Zabdeno 2020-07-01 europa.eu

Trials 22 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT02860650 Aug 2016 → May 2017 Janssen Vaccines & Prevention B.V. Completed No outcome recorded
Phase 1 NCT02376400 Apr → Dec 2015 Crucell Holland BV Completed No outcome recorded
Phase 1 NCT02376426 Mar → Sep 2015 Crucell Holland BV Completed No outcome recorded
Phase 1 NCT02325050 Jan → Jul 2015 Janssen Vaccines & Prevention B.V. Completed No outcome recorded
Phase 1 NCT02313077 Dec 2014 → Apr 2015 Crucell Holland BV Completed No outcome recorded
Phase 29 trials
Phase 2 NCT05284097 Sep 2022 → Mar 2023 Ebola hemorrhagic fever London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 2 NCT05064956 Oct → Nov 2021 Ebola hemorrhagic fever, HIV infectious disease London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 2 NCT04711356 Jul → Sep 2021 Ebola hemorrhagic fever London School of Hygiene and Tropical Medicine Completed No outcome recorded
Phase 2 NCT04186000 Dec 2019 → Apr 2020 Ebola hemorrhagic fever University of Antwerp Completed No outcome recorded
Phase 2 NCT03929757 Aug 2019 → Aug 2022 Ebola hemorrhagic fever Janssen Vaccines & Prevention B.V. Completed No outcome recorded
Phase 2 NCT02876328 Mar 2017 → Dec 2019 Ebola hemorrhagic fever National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 2 NCT02598388 Dec 2015 → Dec 2018 Ebola hemorrhagic fever Janssen Vaccines & Prevention B.V. Completed No outcome recorded
Phase 2 NCT02564523 Nov 2015 → Feb 2019 Ebola hemorrhagic fever Janssen Vaccines & Prevention B.V. Completed No outcome recorded
Phase 2 NCT02416453 Jun 2015 → Jan 2018 Ebola hemorrhagic fever Janssen Vaccines & Prevention B.V. Completed No outcome recorded
Phase 38 trials
Phase 3 NCT06126822 Feb 2025 → Oct 2026 expected Ebola hemorrhagic fever Institute of Tropical Medicine, Belgium Recruiting No outcome recorded
Phase 3 NCT04556526 Oct 2020 → Mar 2023 Janssen Vaccines & Prevention B.V. Completed No outcome recorded
Phase 3 NCT04228783 Feb 2020 → Apr 2022 Ebola hemorrhagic fever Janssen Vaccines & Prevention B.V. Completed No outcome recorded
Phase 3 NCT04152486 Nov 2019 → Jan 2022 Ebola hemorrhagic fever London School of Hygiene and Tropical Medicine Unknown No outcome recorded
Phase 3 NCT02661464 May 2016 → Dec 2021 Ebola hemorrhagic fever Janssen Vaccines & Prevention B.V. Terminated No outcome recorded
Phase 3 NCT02509494 Sep 2015 → Jun 2019 Ebola hemorrhagic fever Janssen Vaccines & Prevention B.V. Completed No outcome recorded
Phase 3 NCT02543567 Sep 2015 → Jun 2016 Janssen Vaccines & Prevention B.V. Completed No outcome recorded
Phase 3 NCT02543268 Sep 2015 → Jan 2016 Crucell Holland BV Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT02495246 Comparator Sep 2015 → Aug 2017 Ebola hemorrhagic fever University of Oxford Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 26 sources stand behind the page.

FieldValueCited text
Known as ADENOVIRUS TYPE 26 ENCODING EBOLA VIRUS GLYCOPROTEIN ChEMBL registry synonym — accepted as the source's own label CHEMBL6068378
Known as Ad26.ZEBOV “The novel 2-dose heterologous Adenovirus type 26.ZEBOV (Ad26.ZEBOV) and modified vaccinia Ankara-BN-Filo (MVA-BN-Filo) vaccine regimen is safe and provides specific immunity...” PMID 32315287 Jul 2020
22

NCT04556526

NCT05284097

NCT02876328

NCT02495246

NCT02543567

NCT02509494

NCT04228783

NCT02564523

NCT03929757

NCT02860650

NCT04186000

NCT04711356

NCT04152486

NCT02376400

NCT02543268

NCT02313077

NCT02376426

NCT02598388

NCT05064956

NCT02325050

NCT02416453

NCT02661464

Known as Adenovirus type 26.ZEBOV “The novel 2-dose heterologous Adenovirus type 26.ZEBOV (Ad26.ZEBOV) and modified vaccinia Ankara-BN-Filo (MVA-BN-Filo) vaccine regimen is safe and provides specific immunity...” PMID 32315287 Jul 2020
Known as Zabdeno ClinicalTrials.gov intervention name — accepted as the source's own label NCT06126822
Modality Vaccine “an adenovirus type 26 vector vaccine encoding Ebola glycoprotein (Ad26.ZEBOV)” PMID 27092831 Apr 2016
Route Intramuscular “administered intramuscularly (IM) as 2-dose heterologous regimens.” NCT02416453