Drugs / AZD1656
last change Sep 2022 re-read 2 minutes ago

AZD1656

Small molecule targets GCK via activation

Developed for
type 2 diabetes mellitus · COVID-19
Investigated by
AstraZeneca · Queen Mary University of London · St George Street Capital

Trials 24 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 118 trials
Phase 1 NCT01221545 Oct 2010 → Jan 2011 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 1 NCT01221519 Sep 2010 → Jan 2011 hyperglycemia, type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 1 NCT01103622 Jun → Dec 2010 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 1 NCT01103609 Apr → Aug 2010 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 1 NCT01096940 Mar → Aug 2010 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 1 NCT01083212 Mar → Jun 2010 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 1 NCT01069926 Mar → Oct 2010 hypoglycemia AstraZeneca Completed No outcome recorded
Phase 1 NCT01095991 Mar → May 2010 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 1 NCT01082120 Feb → May 2010 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 1 NCT00995787 Oct 2009 → Feb 2010 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 26 trials
Phase 2 NCT04516759 Aug 2020 → Apr 2021 COVID-19 St George Street Capital Completed No outcome recorded
Phase 2 NCT05216172 Dec 2019 → Sep 2022 end stage renal failure, type 2 diabetes mellitus Queen Mary University of London Completed No outcome recorded
Phase 2 NCT01152385 May 2010 → May 2011 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 2 NCT01020123 Oct 2009 → Feb 2011 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 2 NCT00856908 Feb → Aug 2009 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 2 NCT00817778 Jan → Jul 2009 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT00817505 Comparator Dec 2008 → Mar 2009 type 1 diabetes mellitus AstraZeneca Completed No outcome recorded
Phase 1 NCT00790153 Comparator Nov 2008 → Feb 2009 type 2 diabetes mellitus AstraZeneca Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 29 sources stand behind the page.

FieldValueCited text
Known as AZD1656 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01020123
25

NCT01152385

NCT00726427

NCT00774553

NCT04516759

NCT00768105

NCT00819884

NCT00916604

NCT01096940

NCT01082120

NCT01095991

NCT00747175

NCT01221545

NCT01221519

NCT00817505

NCT01103622

NCT00817778

NCT05216172

NCT01069926

NCT00995787

NCT00817271

NCT00790153

NCT01103609

NCT00741689

NCT00856908

NCT01083212

Action Activate “activating glucokinase in both the pancreas and the liver” PMID 22943931 Nov 2012
1

“Hexokinase type IV activator” CHEMBL3219124

Modality Small molecule “The trial suggests a beneficial therapeutic effect of AZD1656 and identifies a new therapeutic concept: small molecule activation of endogenous homeostatic immune cells which...” PMID 35996565 Aug 2022
Route Oral “single ascending oral doses of AZD1656” NCT00726427
Target GCK “Hexokinase type IV activator” CHEMBL3219124