Drugs / aminopterin
aminopterin
also known as
AMT · 4-amino-pga · 4-aminofolic acid · 4-aminopteroic acid · AMINOPTERIN SODIUM · Aminopterina de sodio · Aminopterine sodique · Aminopteroylglutamic acid · +6 more
Trials 4 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 2 | NCT03431974 | Nov 2018 → Jan 2021 | psoriasis | Syntrix Biosystems, Inc. | Completed | No outcome recorded |
| Phase 2 | NCT00176462 | Feb 2001 → Sep 2008 | acute lymphoblastic leukemia | Rutgers, The State University of New Jersey | Completed | No outcome recorded |
| Phase 2 | NCT00003821 | Jan 1998 → ? | endometrial cancer | Genzyme, a Sanofi Company | Withdrawn | No outcome recorded |
| Phase 2 | NCT00003305 | Jul 1997 → Sep 2007 | leukemia | Genzyme, a Sanofi Company | Completed | No outcome recorded |
Also used as a comparator or background therapy in 1 trial
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1 | NCT00937027 Comparator | Jun 2009 → Apr 2010 | psoriasis | Syntrix Biosystems, Inc. | Completed | No outcome recorded |
Evidence & citations 18 cited values
Every value below carries the sentence it was read from. 7 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Aminopterin | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03431974 ↗ |
| Known as | 4-amino-pga | ChEMBL registry synonym — accepted as the source's own label CHEMBL376180 ↗ |
| Known as | 4-aminofolic acid | ChEMBL registry synonym — accepted as the source's own label CHEMBL376180 ↗ |
| Known as | 4-aminopteroic acid | ChEMBL registry synonym — accepted as the source's own label CHEMBL376180 ↗ |
| Known as | AMINOPTERIN SODIUM | ChEMBL registry synonym — accepted as the source's own label CHEMBL376180 ↗ |
| Known as | Aminopterina de sodio | ChEMBL registry synonym — accepted as the source's own label CHEMBL376180 ↗ |
| Known as | Aminopterine sodique | ChEMBL registry synonym — accepted as the source's own label CHEMBL376180 ↗ |
| Known as | Aminopteroylglutamic acid | ChEMBL registry synonym — accepted as the source's own label CHEMBL376180 ↗ |
| Known as | Aminotrexate | ChEMBL registry synonym — accepted as the source's own label CHEMBL376180 ↗ |
| Known as | AMT | “N-[4-[[(2,4-diamino-6-pterdinyl)methyl]amino]benzoyl]-L/D-glutamic acid (L/D-AMT) is an investigational drug in phase 1 clinical development that consists of the L-and...” PMID 22653877 ↗ May 20121“LD-aminopterin (AMT) (3 mg (six 0.5 mg tablets).” NCT03431974 ↗ |
| Known as | L/D-AMT | “N-[4-[[(2,4-diamino-6-pterdinyl)methyl]amino]benzoyl]-L/D-glutamic acid (L/D-AMT) is an investigational drug in phase 1 clinical development that consists of the L-and...” PMID 22653877 ↗ May 2012 |
| Known as | LD-Aminopterin | “LD-Aminopterin tablets (0.5 mg tablet) over-encapsulated, 3.0 mg (6 tablets) once orally each week for 14 weeks (14 doses).” NCT03431974 ↗ |
| Known as | Methotrexate related compound b | ChEMBL registry synonym — accepted as the source's own label CHEMBL376180 ↗ |
| Known as | NSC-257456 | ChEMBL registry synonym — accepted as the source's own label CHEMBL376180 ↗ |
| Known as | NSC-739 | ChEMBL registry synonym — accepted as the source's own label CHEMBL376180 ↗ |
| Modality | Small molecule | — CHEMBL376180 ↗ |
| Route | Intravenous | “Aminopterin is administered intravenously over 20 minutes for the first, second, and fourth doses, and orally for the third dose.” NCT00003305 ↗ |
| Route | Oral | “Aminopterin is administered intravenously over 20 minutes for the first, second, and fourth doses, and orally for the third dose.” NCT00003305 ↗ |