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Drugs / Setipiprant
last change May 2018 re-read 2 minutes ago

Setipiprant

also known as ACT-129968 · KYTH-105

Small molecule targets PTGDR2 via inhibition

Developed for
alopecia · asthma · seasonal allergic rhinitis
Investigated by
Idorsia Pharmaceuticals Ltd. · Allergan

Trials 5 · a red edge is where a trial was stopped

today NCT02781311 · Ph 2 NCT02381496 · Ph 1 NCT01877629 · Ph 1 NCT01241214 · Ph 2 NCT01225315 · Ph 2
20112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT02381496 Dec 2011 → Apr 2012 — Idorsia Pharmaceuticals Ltd. Completed No outcome recorded
Phase 1 NCT01877629 Jul 2011 — Idorsia Pharmaceuticals Ltd. Completed No outcome recorded
Phase 23 trials
Phase 2 NCT02781311 Jul 2016 → Mar 2018 alopecia Allergan Completed No outcome recorded
Phase 2 NCT01225315 Nov 2010 → Jan 2012 asthma Idorsia Pharmaceuticals Ltd. Completed No outcome recorded
Phase 2 NCT01241214 Nov 2010 → Feb 2011 seasonal allergic rhinitis Idorsia Pharmaceuticals Ltd. Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 3 NCT01484119 Comparator Dec 2011 → Feb 2012 seasonal allergic rhinitis Idorsia Pharmaceuticals Ltd. Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as setipiprant “a CRTH2 antagonist (setipiprant)” PMID 28392807 ↗ Apr 2017
3

“Drug: Setipiprant” NCT01225315 ↗

NCT02381496 ↗

NCT02781311 ↗
Known as ACT-129968 “Multiple Doses of Setipiprant (ACT-129968)” NCT02381496 ↗
2

NCT01877629 ↗

NCT01484119 ↗
Known as KYTH-105 ChEMBL registry synonym — accepted as the source's own label CHEMBL2386081 ↗
Action Inhibit “G protein-coupled receptor 44 antagonist” CHEMBL2386081 ↗
1

“(CRTH2) antagonist” NCT01877629 ↗
Modality Small molecule “ACT-129968, a tetrahydropyridoindole derivative, is a chemoattractant receptor homologous molecule expressed on T helper 2 cells (CRTH2) antagonist” NCT01877629 ↗
1

CHEMBL2386081 ↗
Route Oral “ACT-129968 (Dose 1, Dose 2, or Dose 3) administered orally twice daily” NCT01225315 ↗
Target PTGDR2 “G protein-coupled receptor 44 antagonist” CHEMBL2386081 ↗