Drugs / ROR1 CAR-specific Autologous T-Lymphocytes
last change Feb 2023 re-read 3 minutes ago

ROR1 CAR-specific Autologous T-Lymphocytes

Cell therapy

Developed for
B-cell chronic lymphocytic leukemia · mantle cell lymphoma · non-small cell lung carcinoma · triple-negative breast carcinoma
Investigated by
Fred Hutchinson Cancer Center · National Cancer Institute (NCI)

Trials 1

201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT02706392 Mar 2016 → May 2021 B-cell chronic lymphocytic leukemia, mantle cell lymphoma, non-small cell lung carcinoma, triple-negative breast carcinoma Fred Hutchinson Cancer Center Terminated No outcome recorded Stop: Enrollment

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as ROR1 CAR-specific Autologous T-Lymphocytes ClinicalTrials.gov intervention name — accepted as the source's own label NCT02706392 ↗
Action Deplete “so they specifically may kill cancer cells with a protein called ROR1 on their surfaces” NCT02706392 ↗
Modality Cell therapy “autologous T-cells engineered to express a ROR1-specific chimeric antigen receptor (ROR1 CAR-T cells)” PMID 36873868 ↗ Feb 2023
Route Intravenous “Given IV” NCT02706392 ↗