Drugs / LY2090314
last change Sep 2015 re-read 2 minutes ago

LY2090314

Small molecule targets GSK3A, GSK3B via inhibition

Developed for
cancer of unknown primary site · leukemia · malignant pancreatic neoplasm
Investigated by
Eli Lilly and Company · Mayo Clinic

Trials 3 · a red edge is where a trial was stopped

20082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT01287520 Nov 2007 → Apr 2011 cancer of unknown primary site Eli Lilly and Company Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT01632306 Mar 2013 → Jun 2015 malignant pancreatic neoplasm Eli Lilly and Company Terminated No outcome recorded
Phase 21 trial
Phase 2 NCT01214603 Nov 2010 → Dec 2012 leukemia Eli Lilly and Company Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as LY2090314 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01287520
2

NCT01214603

NCT01632306

Action Inhibit “LY2090314, a glycogen synthase kinase 3 inhibitor” PMID 26403509 Sep 2015
2

“Glycogen synthase kinase-3 alpha inhibitor” CHEMBL362558

“Glycogen synthase kinase-3 beta inhibitor” CHEMBL362558

Modality Small molecule CHEMBL362558
Route Intravenous “Administered intravenously” NCT01214603
Target GSK3A “Glycogen synthase kinase-3 alpha inhibitor” CHEMBL362558
Target GSK3B “Glycogen synthase kinase-3 beta inhibitor” CHEMBL362558