Drugs / Guanabenz
Guanabenz
also known as
Guanabenz acetate · Guanabenz monoacetate · Guanabenzo · NSC-68982 · NSC-757044 · WY-8678 · WY-8678 ACETATE · Wytensin
Small molecule targets HELZ2 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | WYTENSIN | — | 1982-09-07 | fda.gov ↗ |
Trials 3
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT02423083 | Apr 2015 → Oct 2017 | relapsing-remitting multiple sclerosis | National Institute of Neurological Disorders and Stroke (NINDS) | Terminated | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT05084404 | Oct 2021 → Feb 2023 | NAFLD1, metabolic dysfunction-associated steatohepatitis | Yokohama City University | Unknown | No outcome recorded |
| Phase not applicable1 trial | ||||||
| — | NCT02443103 | May 2015 → Jun 2016 | bone cancer, metastatic neoplasm | Kathy Miller | Terminated | No outcome recorded Stop: Enrollment |
Evidence & citations 13 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Guanabenz | ClinicalTrials.gov intervention name — accepted as the source's own label NCT05084404 ↗ |
| Known as | Guanabenz acetate | “4 mg/day of WY-8678 (guanabenz acetate)” NCT05084404 ↗1“Drug: Guanabenz acetate” NCT02443103 ↗ |
| Known as | Guanabenz monoacetate | ChEMBL registry synonym — accepted as the source's own label CHEMBL420 ↗ |
| Known as | Guanabenzo | ChEMBL registry synonym — accepted as the source's own label CHEMBL420 ↗ |
| Known as | NSC-68982 | ChEMBL registry synonym — accepted as the source's own label CHEMBL420 ↗ |
| Known as | NSC-757044 | ChEMBL registry synonym — accepted as the source's own label CHEMBL420 ↗ |
| Known as | WY-8678 | “4 mg/day of WY-8678 (guanabenz acetate)” NCT05084404 ↗ |
| Known as | WY-8678 ACETATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL420 ↗ |
| Known as | Wytensin | ChEMBL registry synonym — accepted as the source's own label CHEMBL420 ↗ |
| Action | Inhibit | “inhibits Helz2-medaited steatosis in the liver” PMID 35820743 ↗ Jul 2022 |
| Modality | Small molecule | — CHEMBL420 ↗ |
| Route | Oral | “Oral Guanabenz” NCT02423083 ↗ |
| Target | HELZ2 | “binds at a high-affinity constant to a nuclear transcriptional coregulator, helicase with zinc finger 2 (Helz2)” PMID 35820743 ↗ Jul 2022 |