Drugs / AZD3427
last change Aug 2025 re-read 2 minutes ago

AZD3427

targets RXFP1 via activation

Developed for
heart failure · impaired renal function disease · pulmonary hypertension · systolic heart failure
Investigated by
AstraZeneca · Parexel · CTC Clinical Trial Consultants AB · Karolinska Institutet

Trials 4 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT06611423 Oct 2024 → Aug 2025 impaired renal function disease, systolic heart failure AstraZeneca Terminated No outcome recorded
Phase 1 NCT04890548 Nov 2021 → Aug 2022 heart failure AstraZeneca Withdrawn No outcome recorded
Phase 1 NCT04630067 Nov 2020 → Sep 2022 heart failure AstraZeneca Completed No outcome recorded
Phase 21 trial
Phase 2 NCT05737940 Apr 2023 → Jul 2025 heart failure, pulmonary hypertension AstraZeneca Completed No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as AZD3427 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04630067
3

NCT06611423

NCT04890548

NCT05737940

Action Activate “Novel Relaxin Receptor RXFP1 Agonist AZD3427 in the Treatment of Heart Failure:” PMID 39056338 Jul 2024
Route Subcutaneous “by subcutaneous injection” PMID 39056338 Jul 2024
Target RXFP1 “Novel Relaxin Receptor RXFP1 Agonist AZD3427 in the Treatment of Heart Failure:” PMID 39056338 Jul 2024