Drugs / Carlumab
last change Jun 2014 re-read 3 minutes ago

Carlumab

also known as CNTO 888

Monoclonal antibody targets CCL2 via inhibition

Developed for
cancer · prostate cancer · pulmonary fibrosis
Investigated by
Centocor, Inc. · Centocor Research & Development, Inc.

Trials 4

20082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT01204996 May 2010 → Nov 2011 cancer Centocor, Inc. Completed No outcome recorded
Phase 1 NCT00537368 Sep 2007 → Mar 2010 cancer Centocor, Inc. Completed No outcome recorded
Phase 22 trials · 1 missed
Phase 2 NCT00992186 Sep 2009 → Jul 2011 prostate cancer Centocor Research & Development, Inc. Completed No outcome recorded
Phase 2 NCT00786201 Dec 2008 → Jan 2012 pulmonary fibrosis Centocor, Inc. Completed Missed primary

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as Carlumab “Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors” PMID 24928772 ↗ Jun 2014
1

NCT00992186 ↗

Known as CNTO 888 “CNTO 888 is an antibody that works by blocking a protein called CC-chemokine ligand 2 (CCL2).” NCT01204996 ↗
2

NCT00537368 ↗

NCT00786201 ↗

Action Inhibit “CNTO 888 is thought to work by blocking a protein called CC-Chemokine Ligand 2 (CCL2).” NCT00537368 ↗
Modality Monoclonal antibody “CNTO 888 is a monoclonal antibody.” NCT00537368 ↗
Route Intravenous “CNTO 888 is given by intravenous (into the vein) infusion.” NCT00537368 ↗
Target CCL2 “CNTO 888 is thought to work by blocking a protein called CC-Chemokine Ligand 2 (CCL2).” NCT00537368 ↗