Drugs / Vistusertib
last change Jan 2026 re-read 2 minutes ago

Vistusertib

also known as AZD2014 · CC-551 · VISTUSERTIB (AZD2014)

Small molecule targets MTOR via inhibition

Developed for
breast cancer · non-small cell lung carcinoma · cancer · triple-negative breast carcinoma · diffuse large B-cell lymphoma · high grade malignant neoplasm · meningioma · non-small cell squamous lung carcinoma
+23 more · small cell lung carcinoma · childhood malignant neoplasm · clear cell renal carcinoma · diffuse large B-cell lymphoma activated B-cell type · endometrial carcinoma · endometrium adenocarcinoma · estrogen-receptor positive breast cancer · fallopian tube carcinoma · gastric cancer · gastric neoplasm · glioblastoma · hormone receptor-positive breast cancer · infiltrating bladder urothelial carcinoma · metastatic carcinoma · metastatic malignant neoplasm · ovarian serous adenocarcinoma · primary peritoneal carcinoma · prostate cancer · relapsed/refractory diffuse large B-cell lymphoma · Richter transformation · squamous cell lung carcinoma · uterine corpus cancer · gastric adenocarcinoma
Investigated by
AstraZeneca · Samsung Medical Center · Cancer Research UK · Fondation ARC · National Cancer Institute (NCI) · Queen Mary University of London
+21 more · Massachusetts General Hospital · UNICANCER · University of Birmingham · Acerta Pharma BV · Bloodwise · Cambridge University Hospitals NHS Foundation Trust · Canadian Cancer Trials Group · Centre Leon Berard · European Institute of Oncology · Experimental Cancer Medicine Centres · Fight Kids Cancer · French Cooperative Thoracic Intergroup · Gustave Roussy, Cancer Campus, Grand Paris · Institute of Cancer Research, United Kingdom · M.D. Anderson Cancer Center · Mirati Therapeutics Inc. · National Cancer Institute, France · Pfizer · Quintiles, Inc. · Royal Marsden NHS Foundation Trust · United States Department of Defense

Trials 33 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 112 trials
Phase 1 NCT02546661 Dec 2016 → Mar 2020 overdue infiltrating bladder urothelial carcinoma AstraZeneca Active not recruiting No outcome recorded
Phase 1 NCT02619864 Dec 2016 → Mar 2019 glioblastoma Canadian Cancer Trials Group Completed No outcome recorded
Phase 1 NCT02780830 Jun 2016 → Apr 2019 diffuse large B-cell lymphoma activated B-cell type, relapsed/refractory diffuse large B-cell lymphoma AstraZeneca Withdrawn No outcome recorded
Phase 1 NCT02640755 Jan → Dec 2016 cancer AstraZeneca Completed No outcome recorded
Phase 1 NCT02599714 Dec 2015 → Mar 2018 breast cancer AstraZeneca Completed No outcome recorded
Phase 1 NCT02398747 Mar 2015 → Apr 2024 high grade malignant neoplasm AstraZeneca Completed No outcome recorded
Phase 1 NCT02208375 Nov 2014 → Jun 2028 expected BRCA1-related cancer predisposition, BRCA2-related cancer predisposition, endometrium adenocarcinoma, fallopian tube carcinoma +4 M.D. Anderson Cancer Center Active not recruiting No outcome recorded
Phase 1 NCT02064608 Oct 2014 → Dec 2016 prostate cancer Cambridge University Hospitals NHS Foundation Trust Completed No outcome recorded
Phase 1 NCT01884285 Jul 2013 → Mar 2019 castration-resistant prostate carcinoma, non-small cell squamous lung carcinoma, triple-negative breast carcinoma AstraZeneca Completed No outcome recorded
Phase 1 NCT02193633 Apr 2013 → Nov 2017 Royal Marsden NHS Foundation Trust Completed No outcome recorded
Phase 1/25 trials
Phase 1/2 NCT03366103 Mar 2018 → Jul 2021 metastatic malignant neoplasm, small cell lung carcinoma National Cancer Institute (NCI) Terminated No outcome recorded
Phase 1/2 NCT03205046 Jun 2017 → Nov 2019 Richter transformation, diffuse large B-cell lymphoma Acerta Pharma BV Terminated No outcome recorded
Phase 1/2 NCT02813135 Aug 2016 → Feb 2031 expected childhood malignant neoplasm Gustave Roussy, Cancer Campus, Grand Paris Recruiting No outcome recorded
Phase 1/2 NCT02730923 Apr 2016 → Nov 2019 endometrial carcinoma, hormone receptor-positive breast cancer, metastatic carcinoma Centre Leon Berard Unknown No outcome recorded
Phase 1/2 NCT02583542 Jun 2015 → Mar 2020 non-small cell lung carcinoma, squamous cell lung carcinoma, triple-negative breast carcinoma Queen Mary University of London Unknown No outcome recorded
Phase 216 trials
Phase 2 NCT06727357 Sep 2019 → Mar 2025 overdue breast cancer European Institute of Oncology Active not recruiting No outcome recorded
Phase 2 NCT03166176 Mar → Jul 2018 cancer Samsung Medical Center Withdrawn No outcome recorded
Phase 2 NCT03166904 Mar → Jun 2018 cancer Samsung Medical Center Withdrawn No outcome recorded
Phase 2 NCT03334617 Dec 2017 → Sep 2024 overdue non-small cell lung carcinoma AstraZeneca Active not recruiting No outcome recorded
Phase 2 NCT03071874 Oct 2017 → Jun 2022 meningioma Massachusetts General Hospital Unknown No outcome recorded
Phase 2 NCT03106155 Aug 2017 → May 2018 small cell lung carcinoma Samsung Medical Center Terminated No outcome recorded
Phase 2 NCT03061708 Feb 2017 → Nov 2018 gastric neoplasm Samsung Medical Center Terminated No outcome recorded
Phase 2 NCT03082833 Feb 2017 → Nov 2018 gastric cancer Samsung Medical Center Terminated No outcome recorded
Phase 2 NCT02831257 Aug 2016 → May 2019 NF2-related schwannomatosis, meningioma Massachusetts General Hospital Completed No outcome recorded
Phase 2 NCT02752204 Oct 2015 → Sep 2017 diffuse large B-cell lymphoma University of Birmingham Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT02449655 Comparator Feb 2015 → Jul 2018 gastric adenocarcinoma Samsung Medical Center Terminated No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 35 sources stand behind the page.

FieldValueCited text
Known as vistusertib Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer.” PMID 30016392 Sep 2018
10

NCT03205046

NCT03334617

NCT03166904

NCT02664935

NCT03106155

NCT02208375

NCT02546661

NCT02813135

NCT03366103

NCT03166176

Known as AZD2014 “Module E will investigate the safety and tolerability of MEDI4736 given intravenously, in combination with vistusertib (AZD2014) given orally to patients with MIBC whose...” NCT02546661
25

“Vistusertib(AZD2014) is a selective dual mTOR kinase inhibitor targeting both mTORC1 (rapamycin sensitive) and mTORC2 (rapamycin insensitive) complexes of mammalian Target Of...” NCT03166904

“vistusertib(AZD2014): 50 mg BID per os every 12 hours administration daily. One cycle is consisted of 3 weeks.” NCT03106155

AZD2014NCT06727357

NCT01884285

NCT02299999

NCT02730923

NCT01026402

NCT02064608

NCT02449655

NCT02619864

NCT03082833

NCT01793636

NCT01597388

NCT02583542

NCT02752204

NCT02117167

NCT02640755

NCT02398747

NCT02780830

NCT02831257

NCT03061708

NCT02403895

NCT02599714

NCT02216786

NCT03071874

Known as CC-551 ChEMBL registry synonym — accepted as the source's own label CHEMBL2336325
Known as VISTUSERTIB (AZD2014) ChEMBL registry synonym — accepted as the source's own label CHEMBL2336325
Action Inhibit “mTor Kinase Inhibitor AZD2014” NCT01026402
Modality Small molecule CHEMBL2336325
Route Oral “Administered Orally” NCT01597388
Target mTOR mTor Kinase Inhibitor AZD2014” NCT01026402