Drugs / Conjugated Linoleic Acid
last change Jun 2013 re-read 2 minutes ago

Conjugated Linoleic Acid

also known as CLA · Tonalin

targets FASN, THRSP via inhibition

Developed for
breast cancer · cancer · muscular atrophy · obesity disorder
Investigated by
Dartmouth-Hitchcock Medical Center · Cognis · Dartmouth College · Hamilton Health Sciences Corporation · National Cancer Institute (NCI) · University of North Carolina

Trials 4 · a red edge is where a trial was stopped

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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT00908791 Jun 2009 → Mar 2013 breast cancer Dartmouth-Hitchcock Medical Center Completed No outcome recorded
Phase 11 trial
Phase 1 NCT00951158 Mar 2010 → Dec 2012 cancer Dartmouth-Hitchcock Medical Center Terminated No outcome recorded
Phase not applicable2 trials
NCT00347373 Aug 2004 → Sep 2005 obesity disorder University of North Carolina Completed No outcome recorded
NCT00473902 Aug 2003 → Sep 2004 muscular atrophy Hamilton Health Sciences Corporation Completed No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT00204932 Comparator Jul 2004 → Mar 2005 obesity disorder University of Wisconsin, Madison Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Conjugated Linoleic Acid ClinicalTrials.gov intervention name — accepted as the source's own label NCT00473902
4

NCT00347373

NCT00951158

NCT00908791

NCT00204932

Known as CLA “We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM);...” NCT00473902
2

“Conjugated linoleic acid (CLA), a naturally occurring dietary fatty acid, has been found to reduce weight gain and dramatically decrease fat mass in animals.” PMID 16924272 Aug 2006

“Conjugated Linoleic Acid (CLA)” NCT00908791

Known as Tonalin Tonalin Conjugated linoleic acid (dietary supplement)” NCT00347373
Action Inhibit “reduced Spot 14 (THRSP, S14) and Fatty Acid Synthase (FASN) gene expression” NCT00908791
Route Oral oral soft gel capsules will be administered” NCT00908791
Target FASN “reduced Spot 14 (THRSP, S14) and Fatty Acid Synthase (FASN) gene expression” NCT00908791
Target THRSP “reduced Spot 14 (THRSP, S14) and Fatty Acid Synthase (FASN) gene expression” NCT00908791