Drugs / Conjugated Linoleic Acid
last change Jun 2013 re-read 9 days ago

Conjugated Linoleic Acid

also known as CLA · Tonalin

targets FASN, THRSP via inhibition

Developed for
breast cancer · cancer · muscular atrophy · obesity disorder
Investigated by
Dartmouth-Hitchcock Medical Center · Cognis · Dartmouth College · Hamilton Health Sciences Corporation · National Cancer Institute (NCI) · University of North Carolina

Trials 4

2003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial · 1 met primary
Phase 0 NCT00908791 Jun 2009 → Mar 2013 breast cancer Dartmouth-Hitchcock Medical Center Completed Met primary
Phase 11 trial
Phase 1 NCT00951158 Mar 2010 → Dec 2012 cancer Dartmouth-Hitchcock Medical Center Terminated No outcome recorded
Phase not applicable2 trials
— NCT00347373 Aug 2004 → Sep 2005 obesity disorder University of North Carolina Completed No outcome recorded
— NCT00473902 Aug 2003 → Sep 2004 muscular atrophy Hamilton Health Sciences Corporation Completed No outcome recorded
Comparator or background therapy1 trial
Phase 2 NCT00204932 Comparator Jul 2004 → Mar 2005 obesity disorder University of Wisconsin, Madison Completed No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Conjugated linoleic acid ClinicalTrials.gov intervention name — accepted as the source's own label NCT00204932 ↗
4

NCT00347373 ↗

NCT00908791 ↗

NCT00951158 ↗

NCT00473902 ↗

Known as CLA “We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM);...” NCT00473902 ↗
2

“Conjugated linoleic acid (CLA), a naturally occurring dietary fatty acid, has been found to reduce weight gain and dramatically decrease fat mass in animals.” PMID 16924272 ↗ Aug 2006

“Conjugated Linoleic Acid (CLA)” NCT00908791 ↗

Known as Tonalin “Tonalin Conjugated linoleic acid (dietary supplement)” NCT00347373 ↗
Action Inhibit “reduced Spot 14 (THRSP, S14) and Fatty Acid Synthase (FASN) gene expression” NCT00908791 ↗
Route Oral “oral soft gel capsules will be administered” NCT00908791 ↗
Target FASN “reduced Spot 14 (THRSP, S14) and Fatty Acid Synthase (FASN) gene expression” NCT00908791 ↗
Target THRSP “reduced Spot 14 (THRSP, S14) and Fatty Acid Synthase (FASN) gene expression” NCT00908791 ↗