Drugs / AZD1222
last change Jul 2025 re-read 2 minutes ago

AZD1222

Vaccine

Developed for
COVID-19 · cirrhosis of liver · Coronaviridae infectious disease · viral pneumonia · liver disorder
Investigated by
AstraZeneca · University of Oxford · R-Pharm · IQVIA Pty Ltd · Medigen Vaccine Biologics Corp. · Oswaldo Cruz Foundation
+26 more · Russian Direct Investment Fund · The Gamaleya National Center of Epidemiology & Microbiology · Aga Khan University · Albert B. Sabin Vaccine Institute · Assistance Publique - Hôpitaux de Paris · Bill and Melinda Gates Foundation · Botswana Harvard AIDS Institute Partnership · Botswana Ministry of Health · Centro de Pesquisas René Rachou · Chang Gung Memorial Hospital · Coalition for Epidemic Preparedness Innovations · Covance · Escola Nacional de Saúde Pública Sérgio Arouca/Fiocruz · Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória · Federal University of Espirito Santo · Imperial College London · Institute of Liver and Biliary Sciences, India · Medical Research Council, South Africa · Medical University Innsbruck · Medical University of Graz · Medical University of Vienna · Ministerio de Salud de Ciudad Autónoma de Buenos Aires · Shabir Madhi · Stanford University · University of Witwatersrand, South Africa · Wits Health Consortium (Pty) Ltd

Trials 24 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT05007275 Oct 2021 → Jun 2024 COVID-19 Imperial College London Unknown No outcome recorded
Phase 1 NCT04816019 Apr 2021 → Sep 2022 COVID-19 University of Oxford Completed No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT04684446 Sep → Nov 2021 COVID-19 R-Pharm Completed No outcome recorded
Phase 1/2 NCT04760730 Jul 2021 → Mar 2022 COVID-19 R-Pharm Completed No outcome recorded
Phase 1/2 NCT04444674 Jun → Dec 2020 COVID-19 University of Oxford Unknown No outcome recorded
Phase 1/2 NCT04324606 Apr 2020 → Feb 2025 Coronaviridae infectious disease University of Oxford Completed No outcome recorded
Phase 25 trials
Phase 2 NCT05197153 Jan → Jun 2022 Medigen Vaccine Biologics Corp. Completed No outcome recorded
Phase 2 NCT05054621 Sep 2021 → Aug 2022 COVID-19 Chang Gung Memorial Hospital Completed No outcome recorded
Phase 2 NCT05027672 Jul → Aug 2021 Ministerio de Salud de Ciudad Autónoma de Buenos Aires Unknown No outcome recorded
Phase 2 NCT04907331 May → Nov 2021 COVID-19 Medical University Innsbruck Unknown No outcome recorded
Phase 2 NCT04686773 Mar → Oct 2021 COVID-19 R-Pharm Completed No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT04973449 Jun 2021 → Feb 2022 COVID-19 AstraZeneca Completed No outcome recorded
Phase 2/3 NCT05059106 Jun 2021 → Jun 2022 COVID-19 Federal University of Espirito Santo Unknown No outcome recorded
Phase 2/3 NCT04400838 May 2020 → Feb 2025 COVID-19 University of Oxford Completed No outcome recorded
Phase 36 trials
Phase 3 NCT05011526 Oct → Dec 2021 Medigen Vaccine Biologics Corp. Completed No outcome recorded
Phase 3 NCT05028257 Sep 2021 → May 2023 anaphylaxis Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 3 NCT05715944 Sep 2021 → Dec 2022 COVID-19 Botswana Harvard AIDS Institute Partnership Completed No outcome recorded
Phase 3 NCT04540393 Sep → Dec 2020 COVID-19 AstraZeneca Withdrawn No outcome recorded
Phase 3 NCT04516746 Aug 2020 → Mar 2021 COVID-19 AstraZeneca Completed No outcome recorded
Phase 3 NCT04536051 Jun 2020 → Sep 2021 COVID-19 University of Oxford Unknown No outcome recorded
Phase 43 trials
Phase 4 NCT05343871 Jul 2022 → Jul 2023 COVID-19 Albert B. Sabin Vaccine Institute Completed No outcome recorded
Phase 4 NCT05057897 Jan 2022 → Apr 2023 COVID-19 AstraZeneca Terminated No outcome recorded
Phase 4 NCT04914832 Aug 2021 → Sep 2022 COVID-19, viral pneumonia Shabir Madhi Completed No outcome recorded
Phase not applicable1 trial
NCT04794946 Mar 2021 → Mar 2022 cirrhosis of liver Institute of Liver and Biliary Sciences, India Unknown No outcome recorded
Also used as a comparator or background therapy in 16 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/21 trial
Phase 1/2 NCT04568031 Comparator Aug 2020 → Nov 2021 COVID-19 AstraZeneca Completed No outcome recorded
Phase 24 trials
Phase 2 NCT05542693 Comparator Jan → Mar 2023 COVID-19 Azidus Brasil Unknown No outcome recorded
Phase 2 NCT04988048 Comparator Aug → Sep 2021 COVID-19 Ministry of Public Health, Argentina Unknown No outcome recorded
Phase 2 NCT04983537 Comparator Jul → Sep 2021 Ministerio de Salud de Ciudad Autónoma de Buenos Aires Unknown No outcome recorded
Phase 2 NCT04962906 Comparator Jul → Aug 2021 Ministerio de Salud de Ciudad Autónoma de Buenos Aires Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT05012943 Comparator Aug 2021 → Jan 2023 Vinbiocare Biotechnology Joint Stock Company Completed No outcome recorded
Phase 38 trials
Phase 3 NCT05534035 Comparator Feb → Apr 2023 COVID-19 Everest Medicines (Singapore) Pte. Ltd. Unknown No outcome recorded
Phase 3 NCT05572879 Comparator Oct 2022 → Jun 2023 COVID-19 EuBiologics Co.,Ltd Completed No outcome recorded
Phase 3 NCT05198596 Comparator Jul → Nov 2022 Medigen Vaccine Biologics Corp. Completed No outcome recorded
Phase 3 NCT05603052 Comparator Jul 2022 → Jan 2024 COVID-19 EuBiologics Co.,Ltd Completed No outcome recorded
Phase 3 NCT05426343 Comparator Jul → Oct 2022 Medigen Vaccine Biologics Corp. Completed No outcome recorded
Phase 41 trial
Phase 4 NCT04775069 Comparator May 2021 → Sep 2023 liver disorder Humanity & Health Medical Group Limited Completed No outcome recorded
Phase not applicable1 trial
NCT05074368 Comparator Jul 2021 → Apr 2022 National Taiwan University Hospital Completed No outcome recorded

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 48 sources stand behind the page.

FieldValueCited text
Known as AZD1222 “ChAdOx1 nCoV-19 (AZD1222) is a candidate SARS-CoV-2 vaccine comprising a replication-deficient simian adenovirus expressing full-length SARS-CoV-2 spike protein.” PMID 33335323 Dec 2020
24

“Vaccination with reduced dose (half dose) of ChAdOx1 nCoV-19 (AZD1222), in a 2-dose schedule with an interval of 8 weeks” NCT05059106

“2 IM doses (0.5 mL) of AZD1222(Covishield) at Day 0 and after 6-8 weeks of first dose (Day 42-56 days).” NCT04794946

“primary series AZD1222 (ChAdOx1 nCoV-19) vaccination in South African adults aged 18-65 years” PMID 37149443 Apr 2023

“despite widespread use of ChAdOx1 nCoV-19 (AZD1222) as a COVID-2019 booster” PMID 40686533 Jul 2025

“The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved” PMID 33617777 Feb 2021

NCT04516746

NCT05197153

NCT04684446

NCT04760730

NCT04686773

NCT05426343

NCT05715944

NCT04914832

NCT05343871

NCT05011526

NCT04973449

NCT05054621

NCT04864561

NCT04775069

NCT04568031

NCT04540393

NCT05057897

NCT05007275

NCT05198596

Known as Astra Zeneca COVID-19 vaccine “The AstraZeneca COVID-19 Vaccine is a colorless to slightly brown solution, clear to slightly opaque with a pH of 6.6.” NCT05534035
2

Astra Zeneca COVID-19 vaccine (ChAdOx1 nCoV-19)” NCT05012943

“Astra Zeneca COVID19 vaccine” NCT05028257

Known as AstraZeneca (ChAdOx1 nCoV-19 vaccine AZD1222) AstraZeneca (ChAdOx1 nCoV-19 vaccine AZD1222)NCT04988048
Known as Astrazeneca-Oxford “The subjects will be vaccinated with adenovirus-vector COVID-19 vaccine (Astrazeneca-Oxford).” NCT04775069
Known as ChAdOx1 “The purpose of this study is to demonstrate the immunogenicity and safety of AZD1222, AstraZeneca's approved ChAdOx1 vector vaccine against SARS-CoV-2, in SARS-CoV-2...” NCT05057897
1

“We recruited adult volunteers for homologous or heterologous prime-boost vaccinations with adenoviral (ChAdOx1, AstraZeneca) and/or mRNA (mRNA-1273, Moderna) vaccines.” PMID 35305895 Mar 2022

Known as ChAdOx1 nCoV-19 “BACKGROUND: The safety and efficacy of the AZD1222 (ChAdOx1 nCoV-19) vaccine in a large, diverse population at increased risk for severe acute respiratory syndrome coronavirus...” PMID 34587382 Sep 2021
19

“This study will attempt to determine whether administration of a heterologous regimen combining a first dose of Gam-COVID-Vac with a second dose of ChAdOx1 nCoV-19 or...” NCT04962906

“Development of AZD1222, previously referred to as ChAdOx1 nCoV-19, was initiated by the University of Oxford, UK, with subsequent transfer of development activities to AstraZeneca.” NCT04914832

ChAdOx1 nCoV-19 vaccine AZD1222 AstraZeneca-Oxford - United Kingdom.” NCT04988048

“Astra Zeneca's vaccine (ChAdOx1 nCoV-19) as a second dose” NCT05027672

“phase 1/2 trial of AZD1222 (ChAdOx1 nCoV-19) in Japan” PMID 37271703 Jun 2023

“AZD1222 (ChAdOx1 nCoV-19) as third-dose boosters” PMID 37783221 Sep 2023

“Astra Zeneca COVID-19 vaccine (ChAdOx1 nCoV-19)” NCT05012943

“Current/Former names/alias(es):ChAdOx1 nCoV-19NCT05715944

“A Study of Intranasal ChAdOx1 nCOV-19NCT04816019

NCT05603052

NCT04536051

NCT04400838

NCT04444674

NCT04324606

NCT05074368

NCT05059106

NCT04983537

NCT04816019

NCT05572879

Known as ChAdOx1-S “Comparison of Heterologous Vaccination With an Vaxzevria (ChAdOx1-S) Prime and a Comirnaty (BNT162b2) Boost to Homolog Vaccination” NCT04907331
1

“AstraZeneca ChAdOx1-S recombinant AZD1222 vaccine:” NCT05343871

Known as Covishield “Two dose ChAdOx1 nCoV-19 0.5mL (Covishield 0.9 x 10\^11 vp/mL), 4-6 weeks apart” NCT04400838
3

NCT05542693

NCT04794946

NCT05567471

Known as Vaxzevria ClinicalTrials.gov intervention name — accepted as the source's own label NCT05188677
2

NCT05534035

NCT04907331

Modality Vaccine “ChAdOx1 nCoV-19 (AZD1222) is a candidate SARS-CoV-2 vaccine comprising a replication-deficient simian adenovirus expressing full-length SARS-CoV-2 spike protein.” PMID 33335323 Dec 2020
Route Intramuscular “The vaccine will be administered intramuscularly (IM) into the deltoid region of the arm” NCT04324606