Drugs / GSK4532990
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GSK4532990

Developed for
NAFLD1 · alcoholic liver disease
Investigated by
GlaxoSmithKline

Trials 3

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT06613698 Sep 2024 → Aug 2027 expected alcoholic liver disease GlaxoSmithKline Recruiting No outcome recorded
Phase 2 NCT06104319 Jan 2024 → Sep 2025 NAFLD1 GlaxoSmithKline Completed No outcome recorded
Phase 2 NCT05583344 Jan 2023 → Jan 2026 overdue NAFLD1 GlaxoSmithKline Active not recruiting No outcome recorded

News releases announcing trial results or a regulatory action · 2

DateIssuerRelease
2025-11-07 GlaxoSmithKline Results GSK presents data from its advancing liver pipeline at AASLD 2025 gsk.com ↗
Preliminary findings from the GSK ‘990 STARLIGHT study in alcohol-associated liver disease (ALD), show no emerging safety concerns and demonstrate favourable trends in reduced liver enzyme levels despite ongoing alcohol consumption, that may correspond to improvements in hepatocyte ballooning, a significant indicator of liver injury.
2024-11-13 GlaxoSmithKline Results GSK highlights key data from hepatology portfolio at the AASLD’s The Liver Meeting® 2024, emphasising patient impact in areas of high unmet need gsk.com ↗
GSK4532990 HSD17B13 loss-of-function splice variant delays onset of incident metabolic-dysfunction-related and alcohol-related liver disease, slows progression of established liver disease, and lowers risk of liver-related mortality

Evidence & citations 1 cited value

Every value below carries the sentence it was read from. 3 sources stand behind the page.

FieldValueCited text
Known as GSK4532990 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05583344 ↗
2

NCT06613698 ↗

NCT06104319 ↗