Drugs / Pactimibe
Trials 3
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 22 trials · 1 missed | ||||||
| Phase 2 | NCT00185042 | Nov 2002 → Jul 2005 | coronary artery disorder | Daiichi Sankyo | Completed | Missed primary |
| Phase 2 | NCT00185146 | Sep 2002 → Aug 2005 | atherosclerosis | Sankyo Pharma Gmbh | Completed | No outcome recorded |
| Phase 2/31 trial · 1 missed | ||||||
| Phase 2/3 | NCT00151788 | Feb 2004 → Mar 2006 | atherosclerosis, familial hypercholesterolemia | Daiichi Sankyo | Terminated | Missed primary |
News releases announcing trial results or a regulatory action · 1
| Date | Issuer | Release |
|---|---|---|
| 2005-10-26 | Daiichi Sankyo | Results Discontinuation of Clinical Studies of CS-505 (Pactimibe; Sankyo's ACAT Inhibitor) daiichisankyo.com ↗
This decision was made because pactimibe did not meet the primary endpoint in the coronary intravascular ultrasound study (Study 505-202, ACTIVATE). |
All press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2005-10-26 | Daiichi Sankyo | Discontinuation of Clinical Studies of CS-505 (Pactimibe; Sankyo's ACAT Inhibitor) daiichisankyo.com ↗ |
Evidence & citations 8 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Pactimibe | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00151788 ↗ |
| Known as | CS-505 | “Pactimibe, CS-505” NCT00185042 ↗ |
| Known as | Pactimiba | ChEMBL registry synonym — accepted as the source's own label CHEMBL478858 ↗ |
| Known as | PACTIMIBE SULFATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL478858 ↗ |
| Action | Inhibit | “Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT), an intracellular enzyme involved in cholesterol accumulation, with pactimibe was developed to assist in the...” PMID 19293413 ↗ Mar 20092“Acyl coenzyme A:cholesterol acyltransferase 2 inhibitor” CHEMBL478858 ↗ “Acyl coenzyme A:cholesterol acyltransferase 1 inhibitor” CHEMBL478858 ↗ |
| Modality | Small molecule | — CHEMBL478858 ↗ |
| Target | SOAT1 | “Acyl coenzyme A:cholesterol acyltransferase 1 inhibitor” CHEMBL478858 ↗ |
| Target | SOAT2 | “Acyl coenzyme A:cholesterol acyltransferase 2 inhibitor” CHEMBL478858 ↗ |