Drugs / Vepugratinib
last change Dec 2025 re-read 2 minutes ago

Vepugratinib

also known as LY3866288 · LOXO-435
Developed for
metastatic neoplasm · transitional cell carcinoma · urinary bladder neoplasm · metastatic malignant neoplasm · ureter neoplasm · urinary bladder cancer
Investigated by
Eli Lilly and Company

Trials 5 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT06644378 Oct 2024 → Jan 2025 Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT06641037 Oct → Dec 2024 Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT05614739 Jan 2023 → Jun 2027 expected metastatic neoplasm, ureter neoplasm, urinary bladder neoplasm Eli Lilly and Company Recruiting No outcome recorded
Phase 31 trial
Phase 3 NCT07218380 Dec 2025 → Oct 2029 expected metastatic malignant neoplasm, transitional cell carcinoma, urinary bladder cancer Eli Lilly and Company Recruiting No outcome recorded
Phase not stated1 trial
NCT07675057 metastatic neoplasm, transitional cell carcinoma, urinary bladder neoplasm Eli Lilly and Company Available No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as Vepugratinib ClinicalTrials.gov intervention name — accepted as the source's own label NCT07675057
1

NCT07218380

Known as LOXO-435 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05614739
Known as LY3866288 “FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3” NCT05614739
3

“A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract” NCT07218380

NCT06644378

NCT06641037

Route Oral “LOXO-435 administered orally” NCT05614739