Drugs / Parsatuzumab
last change Mar 2017 re-read 3 minutes ago

Parsatuzumab

Monoclonal antibody targets EGFL7 via inhibition

Developed for
colorectal cancer · non-small cell lung carcinoma
Investigated by
Genentech, Inc.

Trials 4

2009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT01075464 Feb 2010 → Apr 2013 — Genentech, Inc. Completed No outcome recorded
Phase 1 NCT00909740 May 2009 → Oct 2011 — Genentech, Inc. Completed No outcome recorded
Phase 22 trials · 2 missed
Phase 2 NCT01399684 Nov 2011 → Feb 2014 colorectal cancer Genentech, Inc. Completed Missed primary
Phase 2 NCT01366131 Jun 2011 → Feb 2013 non-small cell lung carcinoma Genentech, Inc. Completed Missed primary

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Parsatuzumab “This phase II trial evaluated the efficacy of parsatuzumab (also known as MEGF0444A), a humanized anti-EGFL7 IgG1 monoclonal antibody, in combination with modified FOLFOX6...” PMID 28275117 ↗ Mar 2017
Known as anti-EGFL7 monoclonal antibody ChEMBL registry synonym — accepted as the source's own label CHEMBL2109387 ↗
Known as MEGF0444A ClinicalTrials.gov intervention name — accepted as the source's own label NCT01366131 ↗
3

NCT01075464 ↗

NCT01399684 ↗

NCT00909740 ↗

Known as RG-741 ChEMBL registry synonym — accepted as the source's own label CHEMBL2109387 ↗
Known as RG-7414 ChEMBL registry synonym — accepted as the source's own label CHEMBL2109387 ↗
Action Inhibit “Epidermal growth factor-like protein 7 inhibitor” CHEMBL2109387 ↗
Modality Monoclonal antibody “MEGF0444A, a Human IgG1 Antibody” NCT01075464 ↗
Route Intravenous “administered by IV infusion” NCT00909740 ↗
Target EGFL7 “Epidermal growth factor-like protein 7 inhibitor” CHEMBL2109387 ↗