Drugs / para-aminosalicylic acid
last change Dec 2025 re-read 2 minutes ago

para-aminosalicylic acid

also known as PAS
Developed for
multidrug-resistant tuberculosis · pulmonary tuberculosis · rifampicin-resistant tuberculosis
Investigated by
Centre for the AIDS Programme of Research in South Africa · Inje University

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Withdrawn EU (EMA) Granupas (previously Para-aminosalicylic acid Lucane) 2025-12-04 europa.eu
Approved EU (EMA) Granupas (previously Para-aminosalicylic acid Lucane) 2014-04-07 europa.eu

Trials 2 · a red edge is where a trial was stopped

20142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT03070405 Oct 2016 → Mar 2017 Inje University Unknown No outcome recorded
Phase 41 trial
Phase 4 NCT03237182 Jun 2017 → Dec 2022 multidrug-resistant tuberculosis Centre for the AIDS Programme of Research in South Africa Terminated No outcome recorded
Also used as a comparator or background therapy in 3 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT02365623 Background Feb 2015 → Nov 2018 multidrug-resistant tuberculosis Janssen Pharmaceutical K.K. Completed No outcome recorded
Phase 32 trials
Phase 3 NCT06081361 Comparator Dec 2023 → Oct 2026 expected pulmonary tuberculosis, rifampicin-resistant tuberculosis Beijing Chest Hospital Active not recruiting No outcome recorded
Phase 3 NCT02975570 Comparator Aug 2017 → Aug 2021 multidrug-resistant tuberculosis Boston University Withdrawn No outcome recorded

Evidence & citations 3 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as para-aminosalicylic acid “anti-bacterial tuberculosis drugs (pyrazinamide [PZA], ethambutol [EB, EMB], streptomycin [SM], kanamycin [KM, KAN], enviomycin [EVM], ethionamide [TH], cycloserine [CS],...” NCT02365623
4

“either cycloserine or para-aminosalicylic acid, with preference for cycloserine” NCT02975570

“delaminid, para-aminosalicylic acid, imipenem/cilastatin” NCT03237182

NCT06081361

NCT03070405

Known as PAS “para-aminosalicylic acid [PAS]” NCT02365623
Route Oral “Twice daily oral administration from the first day of each period to the seventh dose” NCT03070405