Drugs / Obefazimod
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Obefazimod

also known as ABX464 · SPL-464

Small molecule

Developed for
ulcerative colitis · HIV infectious disease · rheumatoid arthritis · COVID-19 · Crohn disease · Crohn jejunoileitis
Investigated by
Abivax S.A. · Orion Corporation, Orion Pharma · Quotient Sciences

Trials 21 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT07453784 Mar → Sep 2026 expected Abivax S.A. Recruiting No outcome recorded
Phase 1 NCT05032560 Sep 2021 → Feb 2022 Abivax S.A. Completed No outcome recorded
Phase 1 NCT05121714 Dec 2020 → May 2021 Abivax S.A. Completed No outcome recorded
Phase 1 NCT02731885 Sep 2014 → Jun 2015 Abivax S.A. Completed No outcome recorded
Phase 1 NCT02792686 Mar → Jul 2014 Abivax S.A. Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT02990325 Mar 2017 → Dec 2018 HIV infectious disease Abivax S.A. Completed No outcome recorded
Phase 210 trials
Phase 2 NCT06456593 Oct 2024 → Dec 2026 expected Crohn jejunoileitis Abivax S.A. Recruiting No outcome recorded
Phase 2 NCT05177835 Dec 2021 → Mar 2028 expected ulcerative colitis Abivax S.A. Active not recruiting No outcome recorded
Phase 2 NCT04023396 Jan 2020 → Feb 2023 ulcerative colitis Abivax S.A. Completed No outcome recorded
Phase 2 NCT04049448 Oct 2019 → Jan 2023 rheumatoid arthritis Abivax S.A. Completed No outcome recorded
Phase 2 NCT03760003 Aug 2019 → Apr 2021 ulcerative colitis Abivax S.A. Completed No outcome recorded
Phase 2 NCT03813199 Jul 2019 → Apr 2021 rheumatoid arthritis Abivax S.A. Completed No outcome recorded
Phase 2 NCT03368118 Jan 2018 → Jul 2022 ulcerative colitis Abivax S.A. Completed No outcome recorded
Phase 2 NCT03093259 Nov 2017 → Jul 2018 ulcerative colitis Abivax S.A. Completed No outcome recorded
Phase 2 NCT02735863 May 2016 → Aug 2017 HIV infectious disease Abivax S.A. Completed No outcome recorded
Phase 2 NCT02452242 Jan → Dec 2015 HIV infectious disease Abivax S.A. Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT03905109 Sep 2022 Crohn disease Abivax S.A. Withdrawn No outcome recorded
Phase 2/3 NCT04393038 Jul 2020 → Mar 2021 COVID-19 Abivax S.A. Terminated No outcome recorded
Phase 33 trials
Phase 3 NCT05535946 Jan 2023 → Apr 2026 overdue ulcerative colitis Abivax S.A. Active not recruiting No outcome recorded
Phase 3 NCT05507216 Dec 2022 → Jun 2025 ulcerative colitis Abivax S.A. Completed No outcome recorded
Phase 3 NCT05507203 Oct 2022 → Jun 2025 ulcerative colitis Abivax S.A. Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 26 sources stand behind the page.

FieldValueCited text
Known as obefazimod “a first-in-class drug candidate ABX464 (obefazimod, 50 mg and 100 mg per day)” PMID 35641124 Jul 2022
2

NCT07453784

NCT06456593

Known as ABX464 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02452242
18

NCT05032560

NCT05535946

NCT05121714

NCT04393038

NCT02990325

NCT04023396

NCT03368118

NCT02792686

NCT03093259

NCT03905109

NCT02731885

NCT05177835

NCT02735863

NCT03760003

NCT05507216

NCT05507203

NCT04049448

NCT03813199

Known as SPL-464 ChEMBL registry synonym — accepted as the source's own label CHEMBL4297344
Action Inhibit “ABX464 is a novel antiviral that inhibits HIV RNA biogenesis.” PMID 34436569 Jun 2022
Modality Small molecule “ABX464 (obefazimod) is a small moleculePMID 36075249 Sep 2022
Route Oral “The primary objective of the study was to assess the safety and tolerability of ABX464 after repeated oral administrations in subjects infected by HIV.” PMID 28507108 Jun 2017