Drugs / CDX-622
Trials 2
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1 | NCT07330778 | Jun 2026 → Mar 2027 expected | asthma | Celldex Therapeutics | Recruiting | No outcome recorded |
| Phase 1 | NCT06650761 | Nov 2024 → Apr 2026 | — | Celldex Therapeutics | Completed | No outcome recorded |
News releases announcing trial results or a regulatory action · 3
| Date | Issuer | Release |
|---|---|---|
| 2026-06-14 | Celldex Therapeutics | Results Celldex Presents Positive First-in-Human Results from Phase 1 Study of Novel Bispecific CDX-622 at the European Academy of Allergy and Clinical Immunology Annual Meeting celldex.com ↗
Data demonstrated that CDX-622 induced rapid, durable, dose-dependent reductions in serum tryptase, indicative of mast cell depletion, and was well-tolerated at all dose levels. |
| 2025-10-30 | Celldex Therapeutics | Results Celldex Announces Initial Positive Results from Phase 1 Trial of CDX-622 Demonstrating Favorable Safety and PK Profile and Sustained Mast Cell Inhibition celldex.com ↗
CDX-622 was well tolerated, exhibited a good pharmacokinetic profile and induced rapid and sustained reductions in serum tryptase, indicative of mast cell inhibition and depletion. |
| 2023-05-15 | Celldex Therapeutics | Results Celldex Therapeutics Presents Positive Preclinical Data from TSLP/SCF Bispecific Antibody Program CDX-622 at IMMUNOLOGY2023™ celldex.com ↗
The preclinical data show CDX-622 potently neutralizes the alarmin TSLP, a potent mediator of inflammation, and blocks SCF/KIT interaction required for mast cell function and survival. |
All press releases naming this drug 5 releases
Evidence & citations 2 cited values
Every value below carries the sentence it was read from. 2 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | CDX-622 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT06650761 ↗ |
| Route | Intravenous | “IV single ascending doses (Part 1)” NCT06650761 ↗ |