Drugs / ABT-751

Trials 10 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT00047489 Dec 2002 → Jan 2005 hematopoietic and lymphoid cell neoplasm M.D. Anderson Cancer Center Completed No outcome recorded
Phase 1 NCT00036959 Mar 2002 → Feb 2010 central nervous system neoplasm, childhood germ cell tumor, childhood malignant neoplasm, extragonadal germ cell tumor +5 National Institutes of Health Clinical Center (CC) Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT00439296 May 2006 → May 2009 childhood acute lymphoblastic leukemia Therapeutic Advances in Childhood Leukemia Consortium Terminated No outcome recorded
Phase 1/2 NCT00735878 Sep 2004 → Jan 2009 non-small cell lung carcinoma Konstantin Dragnev Terminated No outcome recorded
Phase 1/2 NCT00471718 Jan 2004 → Aug 2009 prostate cancer Vanderbilt-Ingram Cancer Center Terminated No outcome recorded
Phase 25 trials
Phase 2 NCT00436852 Jan 2007 → Sep 2010 neuroblastoma Children's Oncology Group Completed No outcome recorded
Phase 2 NCT00073151 Sep 2003 → Jan 2006 non-small cell lung carcinoma Abbott Completed No outcome recorded
Phase 2 NCT00073138 Aug 2003 → Feb 2005 colorectal cancer Abbott Completed No outcome recorded
Phase 2 NCT00073112 Aug 2003 → Sep 2006 renal cell carcinoma Abbott Completed No outcome recorded
Phase 2 NCT00063102 Nov 2002 → Aug 2004 breast cancer Abbott Completed No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/2 NCT00354562 Comparator Feb 2007 → Feb 2008 non-small cell lung carcinoma Abbott Terminated No outcome recorded
Phase 1/2 NCT00297089 Comparator Nov 2006 → Jan 2009 non-small cell lung carcinoma AbbVie Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 15 sources stand behind the page.

FieldValueCited text
Known as ABT-751 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00471718
11

NCT00297089

NCT00354562

NCT00073112

NCT00735878

NCT00439296

NCT00036959

NCT00436852

NCT00073151

NCT00047489

NCT00073138

NCT00063102

Known as E 7010 ChEMBL registry synonym — accepted as the source's own label CHEMBL20684
Known as NSC-742134 ChEMBL registry synonym — accepted as the source's own label CHEMBL20684
Action Inhibit “ABT-751 is a novel orally administered antimitotic agent that binds to the colchicine site on beta-tubulin and inhibits polymerization of microtubules.” NCT00047489
Modality Other / unclassified “antimitotic and vascular disrupting agent” PMID 21300929 Feb 2011
Route Oral “ABT-751 administered orally once daily for 21 days” PMID 18281544 Feb 2008