Drugs / CLN-081
Trials 6 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT04036682 | Oct 2019 → Oct 2025 overdue | non-small cell lung carcinoma | Cullinan Therapeutics Inc. | Active not recruiting | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT07229339 | Jun 2027 → Jun 2029 expected | non-small cell lung carcinoma | Jonsson Comprehensive Cancer Center | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT05967689 | Jul 2023 → Aug 2028 expected | — | Taiho Oncology, Inc. | Recruiting | No outcome recorded |
| Phase 32 trials | ||||||
| Phase 3 | NCT07128199 | Dec 2025 → Oct 2029 expected | non-small cell lung carcinoma | Taiho Oncology, Inc. | Active not recruiting | No outcome recorded |
| Phase 3 | NCT05973773 | Dec 2023 → Oct 2026 expected | — | Taiho Oncology, Inc. | Active not recruiting | No outcome recorded |
| Phase not stated1 trial | ||||||
| — | NCT07601399 | — | non-small cell lung carcinoma | Taiho Oncology, Inc. | Available | No outcome recorded |
Evidence & citations 8 cited values
Every value below carries the sentence it was read from. 9 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | CLN-081 | “TAS6417/ CLN-081” NCT05967689 ↗ |
| Known as | TAS6417 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT07128199 ↗ |
| Known as | TPC-064 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4650281 ↗ |
| Known as | Zipalertinib | ClinicalTrials.gov intervention name — accepted as the source's own label NCT07229339 ↗ |
| Action | Inhibit | “an irreversible epidermal growth factor receptor (EGFR) inhibitor” PMID 40450572 ↗ Jun 2025 |
| Modality | Small molecule | — CHEMBL4650281 ↗ |
| Route | Oral | “dose levels including 30, 45, 65, 100, and 150 mg orally twice a day” PMID 37384848 ↗ Jun 2023 |
| Target | EGFR | “oral EGFR tyrosine kinase inhibitor” PMID 37384848 ↗ Jun 2023 |