Drugs / Branebrutinib
last change May 2026 re-read 2 minutes ago

Branebrutinib

also known as BMS-986195

Small molecule targets BTK via inhibition

Developed for
rheumatoid arthritis · atopic eczema · Sjogren syndrome · systemic lupus erythematosus
Investigated by
Bristol-Myers Squibb

Trials 8 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 16 trials
Phase 1 NCT05303220 Apr → Aug 2022 Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT04515628 Aug → Oct 2020 Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT03262740 Sep → Dec 2017 rheumatoid arthritis Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT03245515 Aug → Sep 2017 rheumatoid arthritis Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT03131973 May → Nov 2017 rheumatoid arthritis Bristol-Myers Squibb Completed No outcome recorded
Phase 1 NCT02705989 Aug 2016 → Aug 2017 rheumatoid arthritis Bristol-Myers Squibb Completed No outcome recorded
Phase 22 trials
Phase 2 NCT05014438 Aug 2021 → Aug 2022 atopic eczema Bristol-Myers Squibb Completed No outcome recorded
Phase 2 NCT04186871 Jan 2020 → Dec 2022 Sjogren syndrome, rheumatoid arthritis, systemic lupus erythematosus Bristol-Myers Squibb Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 10 sources stand behind the page.

FieldValueCited text
Known as Branebrutinib ClinicalTrials.gov intervention name — accepted as the source's own label NCT05014438
3

NCT05303220

NCT04186871

NCT04515628

Known as BMS-986195 “Efficacy and safety of branebrutinib (BMS-986195), an irreversible Bruton's tyrosine kinase inhibitor, for the treatment of rheumatoid arthritis: a phase 2a, randomised,...” PMID 42081904 May 2026
4

NCT03245515

NCT02705989

NCT03262740

NCT03131973

Action Inhibit “irreversible Bruton's tyrosine kinase inhibitor” PMID 42081904 May 2026
Modality Small molecule CHEMBL4297674
Route Oral “single and multiple ascending oral doses of BMS-986195” NCT02705989
Target BTK “irreversible Bruton's tyrosine kinase inhibitor” PMID 42081904 May 2026